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Frontiers in immunology
2020;11 2030.

Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response.

Min Feng, Shigang Fei, Junming Xia, Vassiliki Labropoulou, Luc Swevers, Jingchen Sun
Author Information
  1. Min Feng: Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.
  2. Shigang Fei: Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.
  3. Junming Xia: Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.
  4. Vassiliki Labropoulou: Insect Molecular Genetics and Biotechnology, Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, Athens, Greece.
  5. Luc Swevers: Insect Molecular Genetics and Biotechnology, Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, Athens, Greece.
  6. Jingchen Sun: Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.
PMID: 32983149 DOI: 10.3389/fimmu.2020.02030

Abstract

Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs.

Keywords

antimicrobial peptides antiviral drugs antiviral peptides insect viruses

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MeSH Term

Animals
Antiviral Agents
Computational Biology
Databases, Factual
Humans
Immunity
Insecta
Pore Forming Cytotoxic Proteins
Species Specificity
Web Browser

Chemicals

Antiviral Agents
Pore Forming Cytotoxic Proteins
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 1

Word Cloud

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