OpenLB
Open Library of Bioscience
Advanced Search
International journal of molecular sciences
Oct 05, 2020;21 (19):

The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides.

Joanna Izabela Lachowicz, Kacper Szczepski, Alessandra Scano, Cinzia Casu, Sara Fais, Germano Orrù, Barbara Pisano, Monica Piras, Mariusz Jaremko
Author Information
  1. Joanna Izabela Lachowicz: Department of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
  2. Kacper Szczepski: Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
  3. Alessandra Scano: Department of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, 09124 Cagliari, Italy.
  4. Cinzia Casu: Department of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, 09124 Cagliari, Italy. ORCID
  5. Sara Fais: Department of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, 09124 Cagliari, Italy.
  6. Germano Orrù: Department of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, 09124 Cagliari, Italy. ORCID
  7. Barbara Pisano: Department of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy. ORCID
  8. Monica Piras: Department of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
  9. Mariusz Jaremko: Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
PMID: 33027928 DOI: 10.3390/ijms21197349

Abstract

Health-care systems that develop rapidly and efficiently may increase the lifespan of humans. Nevertheless, the older population is more fragile, and is at an increased risk of disease development. A concurrently growing number of surgeries and transplantations have caused antibiotics to be used much more frequently, and for much longer periods of time, which in turn increases microbial resistance. In 1945, Fleming warned against the abuse of antibiotics in his Nobel lecture: "The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant". After 70 years, we are witnessing the fulfilment of Fleming's prophecy, as more than 700,000 people die each year due to drug-resistant diseases. Naturally occurring antimicrobial peptides protect all living matter against bacteria, and now different peptidomimetic strategies to engineer innovative antibiotics are being developed to defend humans against bacterial infections.

Keywords

antibiotics antimicrobial peptides metal coplexes peptidomimetics polymers

References

  1. FEBS Lett. 1996 Sep 2;392(3):309-12 [PMID: 8774869]
  2. Front Microbiol. 2018 Nov 27;9:2832 [PMID: 30538681]
  3. Saudi Pharm J. 2016 Sep;24(5):515-524 [PMID: 27752223]
  4. J Am Chem Soc. 2002 Oct 9;124(40):11881-93 [PMID: 12358532]
  5. J Inorg Biochem. 2019 Sep;198:110716 [PMID: 31153112]
  6. Biomacromolecules. 2007 May;8(5):1359-84 [PMID: 17425365]
  7. Nat Rev Drug Discov. 2003 Jul;2(7):587-93 [PMID: 12815383]
  8. Nat Rev Microbiol. 2005 Oct;3(10):777-88 [PMID: 16205711]
  9. Oral Microbiol Immunol. 2008 Aug;23(4):328-35 [PMID: 18582333]
  10. Langmuir. 2015;31(1):404-12 [PMID: 25489959]
  11. J Biol Chem. 2009 Dec 11;284(50):34735-46 [PMID: 19828445]
  12. J Pharm Sci. 2016 Feb;105(2):417-430 [PMID: 26869409]
  13. J Am Chem Soc. 2003 Oct 8;125(40):12092-3 [PMID: 14518985]
  14. J Am Chem Soc. 2009 Jul 22;131(28):9735-45 [PMID: 19601684]
  15. Probiotics Antimicrob Proteins. 2016 Dec;8(4):177-182 [PMID: 27481236]
  16. Prog Lipid Res. 2012 Apr;51(2):149-77 [PMID: 22245454]
  17. Biotechnol Adv. 2020 Nov 15;44:107603 [PMID: 32738381]
  18. FEBS Lett. 1996 Jul 15;390(1):95-8 [PMID: 8706838]
  19. Eur J Biochem. 2003 May;270(10):2207-17 [PMID: 12752440]
  20. Biophys J. 2006 Dec 15;91(12):4413-26 [PMID: 16997878]
  21. Nat Rev Microbiol. 2009 Jan;7(1):25-35 [PMID: 19079350]
  22. J Periodontal Res. 2019 Dec;54(6):589-600 [PMID: 31215656]
  23. J Antimicrob Chemother. 2003 May;51(5):1159-65 [PMID: 12697647]
  24. Biochim Biophys Acta. 1998 Sep 8;1387(1-2):239-48 [PMID: 9748603]
  25. J Pept Sci. 2019 Nov;25(11):e3208 [PMID: 31721374]
  26. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6067-75 [PMID: 27480861]
  27. Biomacromolecules. 2017 Jan 9;18(1):87-95 [PMID: 28064500]
  28. J Am Chem Soc. 2006 Sep 20;128(37):12156-61 [PMID: 16967965]
  29. Adv Exp Med Biol. 2019;1117:175-214 [PMID: 30980359]
  30. J Investig Allergol Clin Immunol. 2014;24(4):212-25; quiz 1p following 225 [PMID: 25219103]
  31. Front Immunol. 2015 Feb 10;6:45 [PMID: 25713575]
  32. Acc Chem Res. 2015 Oct 20;48(10):2696-704 [PMID: 26176689]
  33. Arch Oral Biol. 2015 Mar;60(3):508-15 [PMID: 25555253]
  34. Chem Biol Drug Des. 2011 Jan;77(1):48-56 [PMID: 20942839]
  35. J Pept Sci. 2017 May;23(5):392-402 [PMID: 28299840]
  36. Antimicrob Agents Chemother. 2002 Nov;46(11):3585-90 [PMID: 12384369]
  37. Acc Chem Res. 2008 Oct;41(10):1428-38 [PMID: 18785763]
  38. J Comb Chem. 2009 Mar 9;11(2):294-302 [PMID: 19154119]
  39. Biopolymers. 2006;84(5):435-58 [PMID: 16736494]
  40. Biochim Biophys Acta. 2016 May;1858(5):936-46 [PMID: 26577273]
  41. Biochemistry. 1974 Jan 15;13(2):211-22 [PMID: 4358939]
  42. Drug Discov Today. 2015 Jan;20(1):122-8 [PMID: 25450771]
  43. J Periodontol. 2009 Jun;80(6):969-76 [PMID: 19485828]
  44. Int J Dent Hyg. 2009 May;7(2):121-5 [PMID: 19416094]
  45. Angew Chem Int Ed Engl. 2010;49(2):333-6 [PMID: 19957258]
  46. Int J Mol Sci. 2018 Sep 04;19(9): [PMID: 30181456]
  47. Curr Med Chem. 2017;24(19):2115-2140 [PMID: 28093986]
  48. Microbiol Res. 2015 Jan;170:69-77 [PMID: 25267486]
  49. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2794-9 [PMID: 18287037]
  50. J Am Chem Soc. 2005 Mar 30;127(12):4128-9 [PMID: 15783168]
  51. Molecules. 2018 Feb 14;23(2): [PMID: 29443886]
  52. Mol Microbiol. 2002 Oct;46(1):157-68 [PMID: 12366839]
  53. J Phys Chem B. 2011 Sep 22;115(37):10967-75 [PMID: 21819112]
  54. Int J Food Microbiol. 2001 Dec 4;71(1):1-20 [PMID: 11764886]
  55. Future Microbiol. 2011 Jun;6(6):635-51 [PMID: 21707311]
  56. Eur J Biochem. 2001 Nov;268(21):5589-600 [PMID: 11683882]
  57. ACS Appl Mater Interfaces. 2016 Oct 12;8(40):26501-26510 [PMID: 27644109]
  58. Biochem Biophys Res Commun. 2002 Sep 6;296(5):1044-50 [PMID: 12207877]
  59. Toxicon. 2004 Jul;44(1):67-74 [PMID: 15225564]
  60. Angew Chem Int Ed Engl. 2017 Aug 28;56(36):10826-10829 [PMID: 28660713]
  61. Biochim Biophys Acta. 2014 Mar;1844(3):527-34 [PMID: 24389234]
  62. J Periodontal Res. 2018 Apr;53(2):145-155 [PMID: 28990193]
  63. Curr Top Med Chem. 2017;17(5):508-519 [PMID: 28117020]
  64. Regul Toxicol Pharmacol. 2009 Apr;53(3):209-16 [PMID: 19545513]
  65. Front Microbiol. 2019 Feb 08;10:198 [PMID: 30800115]
  66. Curr Opin Microbiol. 2013 Dec;16(6):779-85 [PMID: 24148302]
  67. Bioconjug Chem. 2004 May-Jun;15(3):530-5 [PMID: 15149180]
  68. Curr Opin Chem Biol. 2017 Jun;38:87-96 [PMID: 28399505]
  69. Drug Resist Updat. 2016 May;26:43-57 [PMID: 27180309]
  70. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14751-6 [PMID: 19706443]
  71. J Colloid Interface Sci. 2010 May 15;345(2):160-7 [PMID: 20185142]
  72. Chem Biol Drug Des. 2013 Jan;81(1):136-47 [PMID: 23253135]
  73. PLoS One. 2013 Dec 23;8(12):e83626 [PMID: 24376726]
  74. Sci Rep. 2019 Jul 29;9(1):10934 [PMID: 31358802]
  75. J Med Chem. 2014 Feb 27;57(4):1428-36 [PMID: 24479371]
  76. Polymers (Basel). 2019 Oct 31;11(11): [PMID: 31683611]
  77. J Biol Chem. 1975 Jan 10;250(1):337-41 [PMID: 237892]
  78. Biomacromolecules. 2016 Sep 12;17(9):3094-102 [PMID: 27442617]
  79. Sci Rep. 2018 Jun 11;8(1):8888 [PMID: 29892005]
  80. Antimicrob Agents Chemother. 2006 Nov;50(11):3923-5 [PMID: 16940073]
  81. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13155-60 [PMID: 26460016]
  82. J Pept Sci. 2009 Sep;15(9):550-8 [PMID: 19455510]
  83. EcoSal Plus. 2018 Aug;8(1): [PMID: 30066669]
  84. Adv Mater. 2016 Jul;28(27):5725-31 [PMID: 26780161]
  85. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6968-73 [PMID: 19359494]
  86. ChemMedChem. 2012 Jan 2;7(1):114-22 [PMID: 21990117]
  87. PLoS One. 2014 Feb 28;9(2):e90397 [PMID: 24587350]
  88. J Biol Chem. 1988 Nov 15;263(32):16709-13 [PMID: 3141410]
  89. J Med Chem. 2009 Apr 9;52(7):2006-15 [PMID: 19296598]
  90. Eur Biophys J. 2011 Apr;40(4):555-64 [PMID: 21312033]
  91. Chembiochem. 2010 Jul 5;11(10):1356-60 [PMID: 20503219]
  92. Eur J Med Chem. 2018 Apr 10;149:248-256 [PMID: 29501945]
  93. Antibiotics (Basel). 2019 Apr 18;8(2): [PMID: 31003540]
  94. Probiotics Antimicrob Proteins. 2019 Jun;11(2):370-381 [PMID: 30229514]
  95. Chem Biol Drug Des. 2016 Apr;87(4):562-8 [PMID: 26577134]
  96. Chem Sci. 2016 Jul 1;7(7):4613-4623 [PMID: 30155109]
  97. Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93 [PMID: 26602694]
  98. Antimicrob Agents Chemother. 2013 Oct;57(10):4632-9 [PMID: 23836163]
  99. Dalton Trans. 2020 Mar 3;49(9):2862-2879 [PMID: 32067003]
  100. Acc Chem Res. 2013 Dec 17;46(12):2977-87 [PMID: 24007507]
  101. Int J Antimicrob Agents. 2006 Jun;27(6):525-9 [PMID: 16713189]
  102. Biomacromolecules. 2009 Jun 8;10(6):1416-28 [PMID: 19354291]
  103. J Biol Chem. 1990 Sep 15;265(26):15365-7 [PMID: 2394727]
  104. Biopolymers. 2002;66(4):236-48 [PMID: 12491537]
  105. AAPS J. 2013 Oct;15(4):897-900 [PMID: 23856740]
  106. Front Microbiol. 2018 Sep 04;9:2085 [PMID: 30233551]
  107. Int J Antimicrob Agents. 2011 Sep;38(3):217-25 [PMID: 21733662]
  108. J Neurosci Res. 1993 Dec 15;36(6):657-62 [PMID: 8145294]
  109. ACS Infect Dis. 2017 Dec 8;3(12):917-926 [PMID: 28960954]
  110. Curr Opin Chem Biol. 2002 Dec;6(6):872-7 [PMID: 12470744]
  111. Nat Commun. 2019 Mar 4;10(1):1012 [PMID: 30833557]
  112. Proc Natl Acad Sci U S A. 1984 Jan;81(1):140-4 [PMID: 6582470]
  113. Anal Chem. 2011 Feb 15;83(4):1342-9 [PMID: 21229969]
  114. J Med Chem. 2015 Jun 11;58(11):4802-11 [PMID: 26020456]
  115. Biochem Cell Biol. 2002;80(5):667-77 [PMID: 12440706]
  116. Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183110 [PMID: 31672543]
  117. Antimicrob Agents Chemother. 1984 Aug;26(2):139-44 [PMID: 6385836]
  118. Front Chem. 2014 Aug 08;2:62 [PMID: 25152873]
  119. ChemMedChem. 2018 Aug 10;13(15):1513-1516 [PMID: 29917316]
  120. J Enzyme Inhib Med Chem. 2004 Feb;19(1):79-84 [PMID: 15202497]
  121. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18953-7 [PMID: 19033194]
  122. Sci Rep. 2017 Feb 14;7:42332 [PMID: 28195195]
  123. Nucleic Acids Res. 2012 Jul;40(Web Server issue):W471-7 [PMID: 22570420]
  124. J Mol Biol. 2008 May 23;379(1):38-50 [PMID: 18440552]
  125. Bioconjug Chem. 2012 May 16;23(5):1069-79 [PMID: 22486390]
  126. Eur J Med Chem. 2018 Jan 1;143:997-1009 [PMID: 29232589]
  127. ACS Infect Dis. 2017 Mar 10;3(3):237-248 [PMID: 28135798]
  128. Biochimie. 2010 Sep;92(9):1236-41 [PMID: 20188791]
  129. J Phys Chem B. 2011 Jan 20;115(2):366-75 [PMID: 21171655]
  130. J Periodontal Res. 2014 Jun;49(3):282-9 [PMID: 23721053]
  131. FEBS Lett. 2004 May 7;565(1-3):171-5 [PMID: 15135074]
  132. ACS Comb Sci. 2016 Jun 13;18(6):287-91 [PMID: 27186808]
  133. Antimicrob Agents Chemother. 1999 May;43(5):1267-9 [PMID: 10223949]
  134. Nat Chem. 2015 Apr;7(4):334-41 [PMID: 25803472]
  135. Drug Discov Today. 2017 Jun;22(6):919-926 [PMID: 28212948]
  136. Eur Biophys J. 2019 Dec;48(8):701-710 [PMID: 31515575]
  137. Biomacromolecules. 2015 Dec 14;16(12):3845-52 [PMID: 26558609]
  138. FEBS Lett. 2001 Aug 24;504(1-2):5-10 [PMID: 11522286]
  139. Biomacromolecules. 2018 Mar 12;19(3):1006-1015 [PMID: 29443506]
  140. J Biol Chem. 2012 Mar 2;287(10):7738-45 [PMID: 22253439]
  141. Colloids Surf B Biointerfaces. 2017 May 1;153:152-159 [PMID: 28236791]
  142. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16393-9 [PMID: 19805310]
  143. J Pept Sci. 2007 Jul;13(7):481-6 [PMID: 17559058]
  144. Periodontol 2000. 2013 Oct;63(1):67-79 [PMID: 23931055]
  145. Nat Mater. 2011 Feb;10(2):149-56 [PMID: 21151166]
  146. Chem Pharm Bull (Tokyo). 1993 May;41(5):978-80 [PMID: 8339345]
  147. Biochemistry. 2019 Sep 10;58(36):3802-3812 [PMID: 31448597]
  148. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4303-8 [PMID: 9539732]
  149. Bioconjug Chem. 2019 Jul 17;30(7):1998-2010 [PMID: 31145591]
  150. Org Lett. 2004 Feb 19;6(4):557-60 [PMID: 14961622]
  151. Biomater Sci. 2020 May 19;8(10):2866-2877 [PMID: 32342076]
  152. J Med Chem. 2015 Jan 22;58(2):625-39 [PMID: 25495219]
  153. Proteins. 2009;77 Suppl 9:100-13 [PMID: 19768687]
  154. Med Res Rev. 2019 May;39(3):831-859 [PMID: 30353555]
  155. Appl Environ Microbiol. 2020 Jan 21;86(3): [PMID: 31757829]
  156. Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406 [PMID: 17158938]
  157. Acta Biomater. 2019 Aug;94:268-280 [PMID: 31129359]
  158. Int J Pharm. 2004 Jun 18;278(1):1-23 [PMID: 15158945]
  159. Biochemistry. 1992 Dec 22;31(50):12688-94 [PMID: 1472506]
  160. J Comput Chem. 2014 Feb 15;35(5):360-70 [PMID: 24293222]
  161. FEMS Microbiol Rev. 1993 Sep;12(1-3):39-85 [PMID: 8398217]
  162. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Dec 5;242:118785 [PMID: 32801024]
  163. ACS Appl Mater Interfaces. 2019 Sep 25;11(38):34609-34620 [PMID: 31448889]
  164. Curr Allergy Asthma Rep. 2009 Sep;9(5):376-83 [PMID: 19671381]
  165. Chemistry. 2009;15(5):1123-33 [PMID: 19072946]
  166. Med Hypotheses. 2020 Nov;144:109967 [PMID: 32575017]
  167. Int J Pharm. 2009 Oct 20;381(1):1-18 [PMID: 19664700]
  168. Nat Rev Microbiol. 2005 Mar;3(3):238-50 [PMID: 15703760]
  169. Pharmaceuticals (Basel). 2016 Sep 20;9(3): [PMID: 27657092]
  170. ACS Infect Dis. 2017 Nov 10;3(11):820-832 [PMID: 28885829]
  171. Angew Chem Int Ed Engl. 2010;49(3):537-40 [PMID: 20014083]
  172. J Med Chem. 2018 Sep 13;61(17):7614-7629 [PMID: 30070835]
  173. J Am Chem Soc. 2002 Jun 26;124(25):7324-30 [PMID: 12071741]
  174. Int J Food Microbiol. 1997 Jan;34(1):1-16 [PMID: 9029252]
  175. J Inorg Biochem. 2017 Feb;167:134-141 [PMID: 27984786]
  176. Biochim Biophys Acta. 1999 Dec 15;1462(1-2):11-28 [PMID: 10590300]
  177. J Biol Chem. 1988 Jun 5;263(16):7472-7 [PMID: 3286634]
  178. Adv Healthc Mater. 2018 Oct;7(20):e1800354 [PMID: 29923332]
  179. J Biol Chem. 2010 May 28;285(22):16880-92 [PMID: 20308076]
  180. Eur Biophys J. 2017 May;46(4):375-382 [PMID: 27832293]
  181. Front Cell Infect Microbiol. 2019 Apr 02;9:84 [PMID: 31001488]
  182. J Am Chem Soc. 2001 Dec 26;123(51):12919-20 [PMID: 11749558]
  183. Biopolymers. 2019 Jun;110(6):e23274 [PMID: 30892696]
  184. Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2365-73 [PMID: 26209560]
  185. Front Chem. 2017 Nov 07;5:86 [PMID: 29164103]
  186. Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1414-1423 [PMID: 29621496]
  187. J Periodontol. 2016 Sep;87(9):1075-82 [PMID: 27177290]
  188. Front Microbiol. 2019 Sep 04;10:2051 [PMID: 31551985]
  189. Front Cell Infect Microbiol. 2015 Dec 24;5:99 [PMID: 26734583]
  190. J Food Sci Technol. 2015 Sep;52(9):5408-17 [PMID: 26344957]
  191. Cell. 1991 Apr 19;65(2):205-7 [PMID: 2015623]
  192. Antimicrob Agents Chemother. 2015 Jul;59(7):4112-20 [PMID: 25941221]
  193. Trends Biotechnol. 2015 Nov;33(11):637-652 [PMID: 26463723]
  194. Antimicrob Agents Chemother. 2010 Oct;54(10):4049-58 [PMID: 20696877]
  195. Front Microbiol. 2013 Dec 09;4:353 [PMID: 24367355]
  196. Acta Biomater. 2017 Feb;49:316-328 [PMID: 27915018]
  197. Biomater Sci. 2019 Apr 23;7(5):2144-2151 [PMID: 30882803]
  198. Nat Biotechnol. 2006 Dec;24(12):1551-7 [PMID: 17160061]
  199. Res Microbiol. 2011 May;162(4):363-74 [PMID: 21320593]
  200. Arch Oral Biol. 2013 May;58(5):451-8 [PMID: 23352445]
  201. J Immunol Methods. 2003 Jul;278(1-2):1-17 [PMID: 12957392]
  202. J Am Chem Soc. 2007 Dec 19;129(50):15474-6 [PMID: 18034491]
  203. Biomacromolecules. 2008 Nov;9(11):2980-3 [PMID: 18850741]
  204. Biochim Biophys Acta. 2014 Oct;1838(10):2492-2502 [PMID: 24878450]
  205. Antimicrob Agents Chemother. 2004 Dec;48(12):4673-9 [PMID: 15561843]
  206. PLoS One. 2014 Sep 04;9(9):e106766 [PMID: 25187958]
  207. J Am Chem Soc. 2004 Dec 8;126(48):15870-5 [PMID: 15571411]
  208. Molecules. 2019 Feb 12;24(3): [PMID: 30759858]
  209. Biomaterials. 2003 Sep;24(20):3563-70 [PMID: 12809785]
  210. Biopolymers. 2016 Mar;106(2):172-183 [PMID: 26662856]
  211. Biochim Biophys Acta Biomembr. 2020 Jul 1;1862(7):183280 [PMID: 32220553]
  212. Org Lett. 2007 Apr 12;9(8):1549-52 [PMID: 17352488]
  213. J Am Chem Soc. 2007 Dec 19;129(50):15615-22 [PMID: 18041836]
  214. Nature. 2000 Apr 6;404(6778):565 [PMID: 10766230]
  215. Biomacromolecules. 2008 Oct;9(10):2805-10 [PMID: 18816096]
  216. Nature. 2002 Jan 24;415(6870):389-95 [PMID: 11807545]
  217. Peptides. 2006 Nov;27(11):2567-74 [PMID: 16730857]
  218. FEBS J. 2013 Jun;280(11):2652-64 [PMID: 23527582]
  219. Annu Rev Microbiol. 1998;52:41-79 [PMID: 9891793]
  220. J Am Chem Soc. 2015 Feb 18;137(6):2183-6 [PMID: 25650957]
  221. Periodontol 2000. 2015 Oct;69(1):96-110 [PMID: 26252404]
  222. Chembiochem. 2001 Jun 1;2(6):445-55 [PMID: 11828476]
  223. Biochim Biophys Acta. 2011 Sep;1808(9):2297-303 [PMID: 21641334]
  224. Biomacromolecules. 2011 Oct 10;12(10):3581-91 [PMID: 21846110]
  225. Nat Rev Microbiol. 2013 Feb;11(2):95-105 [PMID: 23268227]
  226. ACS Appl Mater Interfaces. 2019 Sep 18;11(37):33559-33572 [PMID: 31424189]
  227. Peptides. 2001 Oct;22(10):1675-81 [PMID: 11587796]
  228. RSC Adv. 2019 Mar 7;9(14):7688-7697 [PMID: 35521183]
  229. Antimicrob Agents Chemother. 2017 Mar 24;61(4): [PMID: 28167546]
  230. Chem Commun (Camb). 2014 Jul 7;50(53):7071-4 [PMID: 24854366]
  231. Macromol Biosci. 2011 Nov 10;11(11):1499-504 [PMID: 21818858]
  232. Biomacromolecules. 2009 Nov 9;10(11):3098-107 [PMID: 19803480]
  233. Acc Chem Res. 2016 Mar 15;49(3):428-41 [PMID: 26900964]
  234. J Am Chem Soc. 2008 Jul 30;130(30):9836-43 [PMID: 18593128]
  235. J Am Chem Soc. 2014 Oct 15;136(41):14530-5 [PMID: 25269798]
  236. Nat Commun. 2018 Mar 2;9(1):917 [PMID: 29500445]
  237. Cold Spring Harb Perspect Biol. 2010 May;2(5):a000182 [PMID: 20452952]
  238. BMC Infect Dis. 2006 Jun 13;6:98 [PMID: 16772039]
  239. Eur J Biochem. 2002 Sep;269(17):4367-74 [PMID: 12199716]
  240. Curr Eye Res. 2005 Jul;30(7):505-15 [PMID: 16020284]
  241. Front Microbiol. 2018 Jul 17;9:1603 [PMID: 30065718]
  242. Biochimie. 2002 May-Jun;84(5-6):545-57 [PMID: 12423799]
  243. Chemistry. 2015 Feb 2;21(6):2501-7 [PMID: 25504756]
  244. Stomatologiia (Mosk). 2013;92(1):14-6 [PMID: 23528394]
  245. Biochim Biophys Acta. 2015 Jan;1848(1 Pt B):277-88 [PMID: 25178967]
  246. Biochem Pharmacol. 2017 Jun 1;133:117-138 [PMID: 27663838]
  247. J Mater Chem B. 2016 Apr 7;4(13):2359-2368 [PMID: 32263231]
  248. Biomacromolecules. 2011 Nov 14;12(11):3839-43 [PMID: 21955251]
  249. Chem Rev. 2001 Oct;101(10):3219-32 [PMID: 11710070]
  250. Adv Exp Med Biol. 2019;1117:33-64 [PMID: 30980352]

MeSH Term

Anti-Bacterial Agents
Antimicrobial Cationic Peptides
Bacteria
Bacterial Infections
Humans
Microbial Sensitivity Tests
Peptides
Peptidomimetics

Chemicals

Anti-Bacterial Agents
Antimicrobial Cationic Peptides
Peptides
Peptidomimetics
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0antibioticsmayhumansmuchtimeantimicrobialpeptidesHealth-caresystemsdeveloprapidlyefficientlyincreaselifespanNeverthelessolderpopulationfragileincreasedriskdiseasedevelopmentconcurrentlygrowingnumbersurgeriestransplantationscausedusedfrequentlylongerperiodsturnincreasesmicrobialresistance1945FlemingwarnedabuseNobellecture:"Thecomepenicillincanboughtanyoneshopsdangerignorantmaneasilyunderdoseexposingmicrobesnon-lethalquantitiesdrugmakeresistant"70yearswitnessingfulfilmentFleming'sprophecy700000peopledieyearduedrug-resistantdiseasesNaturallyoccurringprotectlivingmatterbacterianowdifferentpeptidomimeticstrategiesengineerinnovativedevelopeddefendbacterialinfectionsBestPeptidomimeticStrategiesUndercoverAntibacterialPeptidesmetalcoplexespeptidomimeticspolymers

Similar Articles

Cited By