AIM: To quantify the effect of mind-body interventions on stress in pregnant women. DESIGN: A systematic review and meta-analysis of randomized controlled trials was performed. DATA SOURCES: PubMed, Embase, CENTRAL, Web of Science and PsycINFO were searched from each database inception to January 2020. REVIEW METHODS: Randomized controlled trials regarding mind-body interventions for stress in pregnant women were included. Methodological quality was evaluated using the Cochrane Collaboration 'Risk of Bias' tool and meta-analysis was performed via RevMan 5.3. Subgroup analysis and publication bias assessment were conducted. Post hoc sensitivity analysis was performed to investigate the source of heterogeneity. RESULTS: In total, 28 studies comprising 1944 participants were included. The overall meta-analysis showed that antenatal stress of pregnant women in the mind-body interventions groups showed significant high improvements (SMD=-0.94; 95% CI [-1.25, -0.63]; p < .00001) compared with the control groups. Results of subgroup analyses indicated that all types of mind-body interventions including mindfulness intervention, cognitive behavioural therapy, relaxation techniques and yoga were beneficial to antenatal stress. Both groups and individual formats mind-body interventions were effective. 4-8 weeks mind-body interventions were seemed as the optimal choice. Moreover, mind-body interventions were concomitant with reducing antenatal anxiety and depression. CONCLUSION: Mind-body interventions are promising approaches for stress reduction in pregnant women. Nevertheless, the results should be interpreted with caution because of high heterogeneity and publication bias. Further high-quality studies are needed to verify the findings. IMPACT: Mind-body interventions have been widely implemented to ameliorate antenatal stress, but conflicting results were found across studies. This systematic review and meta-analysis suggested that mind-body interventions are relatively safe and convenient and can successfully promote antenatal stress. The suggestions proposed in this review may be useful for developing a scientific mind-body interventions regimen and encouraging the application of mind-body interventions in pregnant women, thereby managing antenatal stress effectively.
Akhter, S., Rutherford, S., & Chu, C. (2017). What makes pregnant workers sick: Why, when, where and how? An exploratory study in the ready-made garment industry in Bangladesh. Reprod Health, 14(142), 1-9. https://doi.org/10.1186/s12978-017-0396-0
Asghari, E., Faramarzi, M., & Mohammmadi, A. (2016). The effect of cognitive behavioural therapy on anxiety, depression and stress in women with preeclampsia. Journal of Clinical and Diagnostic Research, 10(11), QC04-QC07. https://doi.org/10.7860/JCDR/2016/21245.8879
Austin, M. P. V., Middleton, P., Reilly, N. M., & Highet, N. J. (2013). Detection and management of mood disorders in the maternity setting: The Australian Clinical Practice Guidelines. Women Birth, 26(1), 2-9. https://doi.org/10.1016/j.wombi.2011.12.001
Bastani, F., Hidarnia, A., Kazemnejad, A., Vafaei, M., & Kashanian, M. (2005). A randomized controlled trial of the effects of applied relaxation training on reducing anxiety and perceived stress in pregnant women. Journal of Midwifery & Women's Health, 50(4), e36-e40. https://doi.org/10.1016/j.jmwh.2004.11.008
Battle, C., Salisbury, A., Schofield, C., & Ortiz-Hernandez, S. (2013). Perinatal Antidepressant Use: Understanding Women’s Preferences and Concerns. Journal of Psychiatric Practice, 19(6), 443-453. https://doi.org/10.1097/01.pra.0000438183.74359.46
Beattie, J., Hall, H., Biro, M., East, C., & Lau, R. (2017). Effects of mindfulness on maternal stress, depressive symptoms and awareness of present moment experience: A pilot randomised trial. Midwifery, 50, 174-183. https://doi.org/10.1016/j.midw.2017.04.006
Bjelica, A., Cetkovic, N., Trninic-Pjevic, A., & Mladenovic-Segedi, L. (2018). The phenomenon of pregnancy - a psychological view. Ginekologia Polska, 89(2), https://doi.org/10.5603/GP.a2018.0017
Buss, C., Entringer, S., Reyes, J., Chicz-DeMet, A., Sandman, C., Waffarn, F., & Wadhwa, P. (2009). The maternal cortisol awakening response in human pregnancy is associated with the length of gestation. American Journal of Obstetrics & Gynecology, 201(4), 398.e391-e398. https://doi.org/10.1016/j.ajog.2009.06.063.
Chen, C.-H. (2015). Revision and validation of a scale to assess pregnancy stress. The Journal of Nursing Research, 23(1), 25-31. https://doi.org/10.1097/jnr.0000000000000047
Cohen, J. (1962). The statistical power of abnormal-social psychological research: A review. Journal of Abnormal & Social Psychology, 65(3), 145-153. https://doi.org/10.1037/h0045186
DeSocio, J. (2018). Epigenetics, maternal prenatal psychosocial stress and infant mental health. Archives of Psychiatric Nursing, 32(6), 901-906. https://doi.org/10.1016/j.apnu.2018.09.001
Dhillon, A., Sparkes, E., & Duarte, R. V. (2017). Mindfulness-based interventions during pregnancy: A systematic review and meta-analysis. Mindfulness, 8(6), 1421-1437. https://doi.org/10.1007/s12671-017-0726-x
Dunkel-Schetter, C. (2011). Psychological science on pregnancy: Stress processes, biopsychosocial models and emerging research issues. Annual Review of Psychology, 62, 531-558. https://doi.org/10.1146/annurev.psych.031809.130727
Ertekin, P., Duran, A., Daglar, G., Yurtsal, Z., & Cesur, B. (2018). Effect of stress management training on depression, stress and coping strategies in pregnant women: A randomised controlled trial. Journal of Psychosomatic Obstetrics and Gynaecology, 39(3), 203-210. https://doi.org/10.1080/0167482X.2017.1321632
Fiskin, G., & Sahin, N. (2018). Effect of diaphragmatic breathing exercise on psychological parameters in gestational diabetes: A randomised controlled trial. European Journal of Integrative Medicine, 23, 50-56. https://doi.org/10.1016/j.eujim.2018.09.006
Ganpat, T. S., Kurpad, A., Maskar, R., Nagendra, H. R., Abbas, R., Raghuram, N., Anura, K., Rakshani, A., Sudheer, D. C., Rita, M., Ramarao, N. H., Deshpande, C. S., & Nagarathna, R. (2013). Yoga for high-risk pregnancy: A randomized controlled trial. Annals of Medical and Health Sciences Research, 3(3), 341-344. https://doi.org/10.4103/2141-9248.117933
Glover, V. (2014). Prenatal stress and its effects on the fetus and the child: Possi- ble underlying biological mechanisms. Advances in Neurobiology, 10, 269-283. https://doi.org/10.1007/978-1-4939-1372-5_13
Guardino, C., Dunkel Schetter, C., Bower, J., Lu, M., & Smalley, S. (2014). Randomised controlled pilot trial of mindfulness training for stress reduction during pregnancy. Psychology and Health, 29(3), 334-349. https://doi.org/10.1080/08870446.2013.852670
Hall, H. G., Beattie, J., Lau, R., East, C., & Biro, M. A. (2016). Mindfulness and perinatal mental health: A systematic review. Women and Birth, 29(1), 62-71. https://doi.org/10.1016/j.wombi.2015.08.006
Hardy, L., & Reichenbacker, O. (2019). A practical guide to the use of psychotropics during pregnancy and lactation. Archives of Psychiatric Nursing, https://doi.org/10.1016/j.apnu.2019.04.001
Higgins, J., Altman, D., Gøtzsche, P., Jüni, P., Moher, D., Oxman, A., Savović, J., Schulz, K. F., Weeks, L., Sterne, J. A. (2011). The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ-British Medical Journal, 18, 343. https://doi.org/10.1136/bmj.d5928
Higgins, J. P., & S. Green (Eds.) (2011). Cochrane handbook for systematic reviews of interventions (vol. 4). John Wiley & Sons.
Huizink, A. C., Medina, P. G. R. D., Mulder, E. J. H., Visser, G. H. A., & Buitelaar, J. K. (2010). Stress during pregnancy is associated with developmental outcome in infancy. Journal of Child Psychology & Psychiatry, 44(6), 810-818. https://doi.org/10.1111/1469-7610.00166
Jallo, N., Ruiz, R., Elswick, R., & French, E. (2014). Guided imagery for stress and symptom management in pregnant African American women. Evidence-based Complementary and Alternative Medicine, 2014, https://doi.org/10.1155/2014/840923
Kantziari, M., Nikolettos, N., Sivvas, T., Bakoula, C., Chrousos, G., & Darviri, C. (2019). Stress management during the second trimester of pregnancy. International Journal of Stress Management, 26(1), 102-105. https://doi.org/10.1037/str0000078
Khorsandi, M., Vakilian, K., Salehi, B., Goudarzi, M., & Abdi, M. (2016). The effects of stress inoculation training on perceived stress in pregnant women. Journal of Health Psychology, 21(12), 2977-2982. https://doi.org/10.1177/1359105315589800
Krusche, A., Dymond, M., Murphy, S., & Crane, C. (2018). Mindfulness for pregnancy: A randomised controlled study of online mindfulness during pregnancy. Midwifery, 65, 51-57. https://doi.org/10.1016/j.midw.2018.07.005
Kusaka, M., Matsuzaki, M., Shiraishi, M., & Haruna, M. (2016). Immediate stress reduction effects of yoga during pregnancy: One group pre-post test. Women and Birth, 29(5), https://doi.org/10.1016/j.wombi.2016.04.003
Lazarus, R., & Folkman, S. (1984). Stress, appraisal and coping. Springer.
Li, J., Kendall, G., Henderson, S., Downie, J., Landsborough, L., & Oddy, W. (2008). Maternal psychosocial well-being in pregnancy and breastfeeding duration. Acta Paediatrica (Oslo, Norway: 1992), 97(2), 221-225. https://doi.org/10.1111/j.1651-2227.2007.00602.x.
Lönnberg, G., Jonas, W., Unternaehrer, E., Bränström, R., Nissen, E., & Niemi, M. (2020). Effects of a mindfulness based childbirth and parenting program on pregnant women's perceived stress and risk of perinatal depression-Results from a randomized controlled trial. Journal of Affective Disorders, 262, 133-142. https://doi.org/10.1016/j.jad.2019.10.048
Marc, I., Toureche, N., Ernst, E., Hodnett, E. D., Blanchet, C., Dodin, S., & Njoya, M. M. (2011). Mind-body interventions during pregnancy for preventing or treating women's anxiety. Cochrane Database of Systematic Reviews, 7(7), CD007559. https://doi.org/10.1002/14651858.CD007559.pub2
Margenfeld, F., Klocke, C., & Joos, S. (2019). Manual massage for persons living with dementia: A systematic review and meta-analysis. International Journal of Nursing Studies, 96, 132-142. https://doi.org/10.1016/j.ijnurstu.2018.12.012
Mark, M., Baurzhan, M., Tobias, W., & Antino, T. (2019). Engauge Digitizer (software package). Available at: http://markummitchell.github.io/engauge-digitizer/ (Accessed May 2, 2019). https://doi.org/10.5281/zenodo.2656975.
Matvienko-Sikar, K., & Dockray, S. (2017). Effects of a novel positive psychological intervention on prenatal stress and well-being: A pilot randomised controlled trial. Women Birth, 30(2), e111-e118. https://doi.org/10.1016/j.wombi.2016.10.003
Matvienko-Sikar, K., Lee, L., Murphy, G., & Murphy, L. (2016). The effects of mindfulness interventions on prenatal well-being: A systematic review. Psychology and Health, 31(12), 1415-1434. https://doi.org/10.1080/08870446.2016.1220557
Mohammad, M., & Shima, P. (2019). Effect of the combination of Benson’s relaxation technique and brief psychoeducational intervention on multidimensional pain and negative psychological symptoms of pregnant women: A randomized controlled trial. Journal of Education and Health Promotion, 8, 1-7. https://doi.org/10.4103/jehp.jehp_286_18
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2010). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. International Journal of Surgery, 8(5), https://doi.org/10.1016/j.ijsu.2010.02.007
Muthukrishnan, S., Jain, R., Kohli, S., & Batra, S. (2016). Effect of mindfulness meditation on perceived stress scores and autonomic function tests of pregnant Indian women. Journal of Clinical and Diagnostic Research, 10(4), CC05-CC08. https://doi.org/10.7860/JCDR/2016/16463.7679
Nasiri, S., Akbari, H., Tagharrobi, L., & Tabatabaee, A. S. (2018). The effect of progressive muscle relaxation and guided imagery on stress, anxiety and depression of pregnant women referred to health centers. Journal of Education Amd Health Promotion, 7, 41-41. https://doi.org/10.4103/jehp.jehp_158_16
National Institutes of Health (2015). National Centre for Complementary and Integratie Health. NIH.
Nazari, M., Basiri, F., Kaveh, M. H., & Ghaem, H. (2018). Investigating the effect of fordyce happiness cognitive-behavioral training on perceived stress and happiness in pregnant females: Applying the self-efficacy theory. Iranian Red Crescent Medical Journey, 20(10), https://doi.org/10.5812/ircmj.59284
Pan, W., Gau, M., Lee, T., Jou, H., Liu, C., & Wen, T. (2018). Mindfulness-based programme on the psychological health of pregnant women. Women and Birth, 32(1), E102-E109. https://doi.org/10.1016/j.wombi.2018.04.018
Pigott, T. (2012). Advances in meta-analysis. Springer.
Rathbone, A., & Prescott, J. (2017). The use of mobile apps and SMS messaging as physical and mental health interventions: Systematic Review. Journal of Medical Internet Research, 19(8), 295-308. https://doi.org/10.2196/jmir.7740
Richter, J., Bittner, A., Petrowski, K., Junge-Hoffmeister, J., Bergmann, S., Joraschky, P., & Weidner, K. (2012). Effects of an early intervention on perceived stress and diurnal cortisol in pregnant women with elevated stress, anxiety and depressive symptomatology. Journal of Psychosomatic Obstetrics and Gynaecology, 33(4), 162-170. https://doi.org/10.3109/0167482x.2012.729111
Roca, A., Imaz, M. L., Torres, A., Plaza, A., Subirà, S., Valdés, M., Martin-Santos, R., & Garcia-Esteve, L. L. (2013). Unplanned pregnancy and discontinuation of SSRIs in pregnant women with previously treated affective disorder. Journal of Affective Disorders, 150(3), 807-813. https://doi.org/10.1016/j.jad.2013.02.040
Satyapriya, M., Nagendra, H., Nagarathna, R., & Padmalatha, V. (2009). Effect of integrated yoga on stress and heart rate variability in pregnant women. International Journal of Gynaecology and Obstetrics, 104(3), 218-222. https://doi.org/10.1016/j.ijgo.2008.11.013
Scherer, S., Alder, J., Gaab, J., Berger, T., Ihde, K., & Urech, C. (2016). Patient satisfaction and psychological well-being after internet-based cognitive behavioral stress management (IB-CBSM) for women with preterm labor: A randomized controlled trial. Journal of Psychosomatic Research, 80, 37-43. https://doi.org/10.1016/j.jpsychores.2015.10.011
Shahtaheri, E., Hosseinian, S., Ebrahimi, M., Jalilabadi Z., & Mirderikvand, F. (2016). The impact of stress reduction program based on mindfulness and conscious yoga on depression, perceived stress and quality of life in pregnant women. Acta Medica Mediterr, 32(5), 2047-2050.
Staneva, A., Bogossian, F., & Wittkowski, A. (2015). The experience of psychological distress, depression, and anxiety during pregnancy: A Meta-synthesis of qualitative research. Midwifery, 31(6), 563-573. https://doi.org/10.1016/j.midw.2015.03.015
Taylor, B. L., Cavanagh, K., & Strauss, C. (2016). The effectiveness of mindfulness-based interventions in the perinatal period: A systematic review and meta-analysis. PLoS One, 11(5), https://doi.org/10.1371/journal.pone.0155720
Tragea, C., Chrousos, G., Alexopoulos, E., & Darviri, C. (2014). A randomized controlled trial of the effects of a stress management programme during pregnancy. Complementary Therapies in Medicine, 22(2), 203-211. https://doi.org/10.1016/j.ctim.2014.01.006
Urech, C., Scherer, S., Emmenegger, M., Gaab, J., Tschudin, S., Hoesli, I., Berger, T., & Alder, J. (2017). Efficacy of an internet-based cognitive behavioral stress management training in women with idiopathic preterm labor: A randomized controlled intervention study. Journal of Psychosomatic Research, 103, 140-146. https://doi.org/10.1016/j.jpsychores.2017.10.014
Urizar, G., Yim, I., Rodriguez, A., & Schetter, C. (2019). The SMART Moms Program: A Randomized trial of the impact of stress management on perceived stress and cortisol in low-income pregnant women. Psychoneuroendocrinology, 104, 174-184. https://doi.org/10.1016/j.psyneuen.2019.02.022
Van den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., & Schwab, M. (2017). Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy. Neuroscience and Biobehavioral Reviews, https://doi.org/10.1016/j.neubiorev.2017.07.003
Vieten, C., & Astin, J. (2008). Effects of a mindfulness-based intervention during pregnancy on prenatal stress and mood: Results of a pilot study. Archives of Women's Mental Health, 11(1), 67-74. https://doi.org/10.1007/s00737-008-0214-3
Woods, S., Melville, J., Guo, Y., Fan, M., & Gavin, A. (2010). Psychosocial stress during pregnancy. American Journal of Obstetrics & Gynecology, 202(1), 61.e61-.e67. https://doi.org/10.1016/j.ajog.2009.07.041
Woolhouse, H., Mercuri, K., Judd, F., & Brown, S. (2014). Antenatal mindfulness intervention to reduce depression, anxiety and stress: A pilot randomised controlled trial of the MindBabyBody program in an Australian tertiary maternity hospital. BMC Pregnancy Childbirth, 14, 369. https://doi.org/10.1186/s12884-014-0369-z
Zaheri, H., Najar, S., & Abbaspoor, Z. (2017). Effectiveness of cognitive-behavioral stress management on psychological stress and glycemic control in gestational diabetes: A randomized controlled trial. The Journal of Maternal-Fetal & Neonatal Medicine, 30(11), 1378-1382. https://doi.org/10.1080/14767058.2016.1214699
Zhang, H., & Emory, E. (2015). A mindfulness-based intervention for pregnant African-American women. Mindfulness, 6(3), 663-674. https://doi.org/10.1007/s12671-014-0304-4
Zhang, J., Cui, Y., Zhou, Y., & Li, Y. (2019). Effects of mindfulness-based stress reduction on prenatal stress, anxiety and depression. Psychology, Health & Medicine, 24(1), 51-58. https://doi.org/10.1080/13548506.2018.1468028