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10 09, 2020;12 (10):

Review of Hepatitis E Virus in Rats: Evident Risk of Species to Human Zoonotic Infection and Disease.

Gábor Reuter, Ákos Boros, Péter Pankovics
Author Information
  1. Gábor Reuter: Department of Medical Microbiology and Immunology, Medical School, University of Pécs, H-7624 Pécs, Hungary. ORCID
  2. Ákos Boros: Department of Medical Microbiology and Immunology, Medical School, University of Pécs, H-7624 Pécs, Hungary. ORCID
  3. Péter Pankovics: Department of Medical Microbiology and Immunology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
PMID: 33050353 DOI: 10.3390/v12101148

Abstract

Hepatitis E virus (HEV) (family ) is one of the most common human pathogens, causing acute hepatitis and an increasingly recognized etiological agent in chronic hepatitis and extrahepatic manifestations. Recent studies reported that not only are the classical members of the species (HEV-A) pathogenic to humans but a genetically highly divergent rat origin hepevirus (HEV-C1) in species (HEV-C) is also able to cause zoonotic infection and symptomatic disease (hepatitis) in humans. This review summarizes the current knowledge of hepeviruses in rodents with special focus of rat origin HEV-C1. Cross-species transmission and genetic diversity of HEV-C1 and confirmation of HEV-C1 infections and symptomatic disease in humans re-opened the long-lasting and full of surprises story of HEV in human. This novel knowledge has a consequence to the epidemiology, clinical aspects, laboratory diagnosis, and prevention of HEV infection in humans.

Keywords

cross-species transmission hepatitis hepatitis E virus hepevirus human orthohepevirus rat reservoir rodent zoonosis

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MeSH Term

Animals
Cell Line
Disease Reservoirs
Genome, Viral
Hepatitis E
Hepatitis E virus
Hepatitis, Viral, Animal
Hepevirus
Humans
Phylogeny
Rats
Zoonoses
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 3

Word Cloud

Created with Highcharts 10.0.0hepatitishumansHEV-C1EHEVhumanratHepatitisvirusspeciesoriginhepevirusinfectionsymptomaticdiseaseknowledgetransmissionfamilyonecommonpathogenscausingacuteincreasinglyrecognizedetiologicalagentchronicextrahepaticmanifestationsRecentstudiesreportedclassicalmembersHEV-ApathogenicgeneticallyhighlydivergentHEV-CalsoablecausezoonoticreviewsummarizescurrenthepevirusesrodentsspecialfocusCross-speciesgeneticdiversityconfirmationinfectionsre-openedlong-lastingfullsurprisesstorynovelconsequenceepidemiologyclinicalaspectslaboratorydiagnosispreventionReviewVirusRats:EvidentRiskSpeciesHumanZoonoticInfectionDiseasecross-speciesorthohepevirusreservoirrodentzoonosis

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