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Bulletin de l'Academie nationale de medecine
Dec, 2020;204 (9): 981-988.

[From the bench to the clinic: The challenge of translating platelet production in vitro].

G Bouet, S Mookerjee, H Foster, A Waller, C Ghevaert
Author Information
  1. G Bouet: Mines Saint-Étienne, université Lyon, université Jean-Monnet, Inserm, U 1059 Sainbiose, Centre CIS, Saint-Étienne, France.
  2. S Mookerjee: Wellcome trust-medical research council Cambridge Stem Cell Institute and department of haematology, university of Cambridge, CB2 0PT Cambridge, UK.
  3. H Foster: Wellcome trust-medical research council Cambridge Stem Cell Institute and department of haematology, university of Cambridge, CB2 0PT Cambridge, UK.
  4. A Waller: Wellcome trust-medical research council Cambridge Stem Cell Institute and department of haematology, university of Cambridge, CB2 0PT Cambridge, UK.
  5. C Ghevaert: Wellcome trust-medical research council Cambridge Stem Cell Institute and department of haematology, university of Cambridge, CB2 0PT Cambridge, UK.
PMID: 33078026 DOI: 10.1016/j.banm.2020.10.004

Abstract

Platelet transfusions, which are currently totally dependent on altruistic donations, are absolutely necessary to the treatment of patients with thrombocytopenia following trauma, surgery or other pathologies (especially malignancies). Producing platelets in vitro represent a major technological and scientific breathrough that would address logistical issues (supply chain, stock holding…) and medical concerns (compatibility and biosafety). The translation of this innovation will need to be accompanied by rigorous quality control, harmonised between laboratory when it comes to functionality and biosafety for use in the clinic.

Keywords

Biosafety In vitro Platelets Quality control Transfusion

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Grants

  1. MC_PC_12009/Medical Research Council
  2. MC_PC_17230/Medical Research Council
English Abstract Journal Article Review

Word Cloud

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