9G Test Cancer/Lung: A Desirable Companion to LDCT for Lung Cancer Screening.
Wonho Choe, Jeong Don Chae, Byoung-Hoon Lee, Sang-Hoon Kim, So Young Park, Satish Balasaheb Nimse, Junghoon Kim, Shrikant Dashrath Warkad, Keum-Soo Song, Ae-Chin Oh, Young Jun Hong, Taisun Kim
Author Information
Wonho Choe: Nowon Eulji Medical Center, Department of Laboratory Medicine, Eulji University, Seoul 01830, Korea.
Jeong Don Chae: Nowon Eulji Medical Center, Department of Laboratory Medicine, Eulji University, Seoul 01830, Korea.
Byoung-Hoon Lee: Nowon Eulji Medical Center, Department of Pulmonology and Allergy, Eulji University, Seoul 01830, Korea.
Sang-Hoon Kim: Nowon Eulji Medical Center, Department of Pulmonology and Allergy, Eulji University, Seoul 01830, Korea.
So Young Park: Nowon Eulji Medical Center, Department of Pulmonology and Allergy, Eulji University, Seoul 01830, Korea.
Satish Balasaheb Nimse: Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 24252, Korea. ORCID
Junghoon Kim: Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 24252, Korea.
Shrikant Dashrath Warkad: Biometrix Technology, Inc. 2-2 Bio Venture Plaza 56, Chuncheon 24232, Korea.
Keum-Soo Song: Biometrix Technology, Inc. 2-2 Bio Venture Plaza 56, Chuncheon 24232, Korea.
Ae-Chin Oh: Departments of Laboratory Medicine, Korea Cancer Center Hospital, Seoul 01812, Korea. ORCID
Young Jun Hong: Departments of Laboratory Medicine, Korea Cancer Center Hospital, Seoul 01812, Korea. ORCID
Taisun Kim: Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 24252, Korea.
A complimentary biomarker test that can be used in combination with LDCT for lung cancer screening is highly desirable to improve the diagnostic capacity of LDCT and reduce the false-positive rates. Most importantly, the stage I lung cancer detection rate can be dramatically increased by the simultaneous use of a biomarker test with LDCT. The present study was conducted to evaluate 9G test Cancer/Lung's sensitivity and specificity in detecting Stage 0~IV lung cancer. The obtained results indicate that the 9G test Cancer/Lung can detect lung cancer with overall sensitivity and specificity of 75.0% (69.1~80.3) and 97.3% (95.0~98.8), respectively. The detection of stage I, stage II, stage III, and stage IV cancers with sensitivities of 77.5%, 78.1%, 67.4%, and 33.3%, respectively, at the specificity of 97.3% have never been reported before. The receiver operating characteristic curve analysis allowed us to determine the population-weighted AUC of 0.93 (95% CI, 0.91-0.95). These results indicate that the 9G test Cancer/Lung can be used in conjunction with LDCT to screen lung cancer. Furthermore, obtained results indicate that the use of 9G test Cancer/Lung with LDCT for lung cancer screening can increase stage I cancer detection, which is crucial to improve the currently low 5-year survival rates.
