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Hormones (Athens, Greece)
Mar, 2021;20 (1): 23-33.

Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: systematic review and meta-analysis.

Mousa Khalafi, Karim Azali Alamdari, Michael E Symonds, Hadi Nobari, Jorge Carlos-Vivas
Author Information
  1. Mousa Khalafi: Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, 4199613776, Iran. mousa.khalafi@ut.ac.ir. ORCID
  2. Karim Azali Alamdari: Department of Sport Sciences, Azarbaijan Shahid Madani University, Tabriz, 5375171379, Iran. k.azali@azaruniv.ac.ir.
  3. Michael E Symonds: The Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, and Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.
  4. Hadi Nobari: Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran.
  5. Jorge Carlos-Vivas: Health, Economy, Motricity and Education Research Group (HEME), Faculty of Sport Sciences, University of Extremadura, 10003, Caceres, Spain.
PMID: 33151509 DOI: 10.1007/s42000-020-00245-3

Abstract

PURPOSE/OBJECTIVE: The aim of this study was to quantify circulating fibroblast growth factor 21 (FGF-21) changes during and immediately after acute exercise and, based on body weight, to identify the subgroups exhibiting the largest response.
METHODS: The PubMed, Web of Science, and Cochrane Library electronic databases were searched up to December 2019 for studies published in English peer-reviewed journals. Studies that evaluated the effects of acute exercise on FGF-21 concentrations immediately after and 1 and 3 h post-exercise in adults were included. Random effects models were used for analyses, with data reported as standardized mean difference (SMD) and 95% confidence interval, and the risk of heterogeneity was evaluated. Subgroup analysis of subjects with normal weight and obesity/overweight was performed.
RESULTS: A total of seven studies involving 125 participants (age 35.95 (21-64) years and BMI 25.89 (21.30-35.46) kg/m) were included. Overall, acute exercise increased FGF-21 (d = 0.18; 95% CI 0.01 to 0.35, p = 0.02) and this remained for 1 h post-exercise FGF-21 (d = 0.59; 95% CI 0.33 to 0.86, p = 0.001). Three hours after exercise, FGF-21 was restored to near baseline values (d = - 0.05; 95% CI - 0.34 to 0.22, p = 0.68). Acute exercise raised FGF-21 concentrations in normal weight participants (d = 0.57, p = 0.001) and tended to increase in overweight and obese participants (d = 0.79, p = 0.05) 1 h post-exercise.
CONCLUSION: Acute exercise increases circulating FGF-21, irrespective of body weight.

Keywords

Acute exercise FGF-21 Hepatokine Obesity Type 2 diabetes

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MeSH Term

Adult
Body Weight
Exercise
Fibroblast Growth Factors
Gene Expression Regulation
Humans

Chemicals

fibroblast growth factor 21
Fibroblast Growth Factors
Journal Article Meta-Analysis Systematic Review

Word Cloud

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