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Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Apr, 2021;259 (4): 883-889.

Choroidal thickening in retinal vein occlusion patients with serous retinal detachment.

Lulu Chen, Mingzhen Yuan, Lu Sun, Youxin Chen
Author Information
  1. Lulu Chen: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
  2. Mingzhen Yuan: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
  3. Lu Sun: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
  4. Youxin Chen: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. yxchenpumch@outlook.com. ORCID
PMID: 33205242 DOI: 10.1007/s00417-020-04983-3

Abstract

PURPOSE: To evaluate choroid thickness and macular retinal metrics in treatment naïve retinal vein occlusion (RVO) patients with serous retinal detachment (SRD) before and after intravitreal anti-vascular endothelial cell growth factor (VEGF) injection and to elucidate the possible role of choroid in the development of SRD and the potential role of SRD as a prognostic parameter.
METHODS: This is a retrospective study involving 85 RVO patients, 41 central retinal vein occlusion (CRVO), and 44 branch retinal vein occlusion (BRVO), with macular edema: 21 central retinal vein occlusion and 22 branch retinal vein occlusion with SRD and the rest without SRD. Patients were evaluated with ophthalmic examinations and swept-source optical coherence tomography (SS-OCT) both before and 4-6 weeks after intravitreal anti-VEGF treatment. Choroid thickness and retinal metrics were measured and compared between SRD and non-SRD groups within each RVO subtype.
RESULTS: In both CRVO and BRVO patients, the mean central subfield foveal thickness (CSFT) and central subfoveal choroid thickness (CSCT) of the SRD groups were thicker than those in the non-SRD groups (p < 0.05) at onset. After one anti-VEGF injection, CSFT and FNRT decreased in all groups (p < 0.05). The CSCTs were thicker in the SRD groups compared with the non-SRD groups (p < 0.05). The mean changes of CSFT were more remarkable in the SRD groups (p < 0.05).
CONCLUSION: Thicker choroid was a feature of naïve RVO patients with SRD and SRD may be an indicator of better anatomical recovery of retina in RVO patients after a single dose of anti-VEGF treatment.

Keywords

Retinal vein occlusion Serous retinal detachment

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MeSH Term

Choroid
Fluorescein Angiography
Humans
Retinal Detachment
Retinal Vein Occlusion
Retrospective Studies
Visual Acuity
Journal Article
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0retinalSRDveinocclusiongroupspatientsRVOchoroidthicknesscentralp < 005treatmentdetachmentanti-VEGFnon-SRDCSFTmacularmetricsnaïveserousintravitrealinjectionroleCRVObranchBRVOcomparedmeanthickerPURPOSE:evaluateanti-vascularendothelialcellgrowthfactorVEGFelucidatepossibledevelopmentpotentialprognosticparameterMETHODS:retrospectivestudyinvolving854144edema:2122restwithoutPatientsevaluatedophthalmicexaminationsswept-sourceopticalcoherencetomographySS-OCT4-6 weeksChoroidmeasuredwithinsubtypeRESULTS:subfieldfovealsubfovealCSCTonsetoneFNRTdecreasedCSCTschangesremarkableCONCLUSION:ThickerfeaturemayindicatorbetteranatomicalrecoveryretinasingledoseChoroidalthickeningRetinalSerous

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