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Biology direct
11 19, 2020;15 (1): 25.

Commensal microbes and p53 in cancer progression.

Ivana Celardo, Gerry Melino, Ivano Amelio
Author Information
  1. Ivana Celardo: MRC Toxicology Unit, University of Cambridge, Cambridge, UK.
  2. Gerry Melino: Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, Italy.
  3. Ivano Amelio: Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, Italy. ivano.amelio@uniroma2.it. ORCID
PMID: 33213502 DOI: 10.1186/s13062-020-00281-4

Abstract

Aetiogenesis of cancer has not been fully determined. Recent advances have clearly defined a role for microenvironmental factors in cancer progression and initiation; in this context, microbiome has recently emerged with a number of reported correlative and causative links implicating alterations of commensal microbes in tumorigenesis. Bacteria appear to have the potential to directly alter physiological pathways of host cells and in specific circumstances, such as the mutation of the tumour suppressive factor p53, they can also directly switch the function of a gene from oncosuppressive to oncogenic. In this minireview, we report a number of examples on how commensal microbes alter the host cell biology, affecting the oncogenic process. We then discuss more in detail how interaction with the gut microbiome can affect the function of p53 mutant in the intestinal tumorigenesis.

Keywords

Microbiota Microenvironment Oncogenes Tumour suppression p53

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Grants

  1. 23219/Associazione Italiana per la Ricerca sul Cancro
  2. 20473/Associazione Italiana per la Ricerca sul Cancro

MeSH Term

Animals
Carcinogenesis
Gastrointestinal Microbiome
Humans
Intestines
Symbiosis
Tumor Suppressor Protein p53

Chemicals

Tumor Suppressor Protein p53
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 2

Word Cloud

Created with Highcharts 10.0.0p53cancermicrobesprogressionmicrobiomenumbercommensaltumorigenesisdirectlyalterhostcanfunctiononcogenicAetiogenesisfullydeterminedRecentadvancesclearlydefinedrolemicroenvironmentalfactorsinitiationcontextrecentlyemergedreportedcorrelativecausativelinksimplicatingalterationsBacteriaappearpotentialphysiologicalpathwayscellsspecificcircumstancesmutationtumoursuppressivefactoralsoswitchgeneoncosuppressiveminireviewreportexamplescellbiologyaffectingprocessdiscussdetailinteractiongutaffectmutantintestinalCommensalMicrobiotaMicroenvironmentOncogenesTumoursuppression

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