Absence of Alleviates Negative Growth Effects of Colistin Resistance in .

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Jessie E Wozniak, Aroon T Chande, Eileen M Burd, Victor I Band, Sarah W Satola, Monica M Farley, Jesse T Jacob, I King Jordan, David S Weiss

Author Information

Jessie E Wozniak: Emory Vaccine Center, Atlanta, GA 30317, USA.
Aroon T Chande: Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332, USA. ORCID
Eileen M Burd: School of Medicine, Emory University, Atlanta, GA 30322, USA. ORCID
Victor I Band: Emory Vaccine Center, Atlanta, GA 30317, USA.
Sarah W Satola: School of Medicine, Emory University, Atlanta, GA 30322, USA.
Monica M Farley: School of Medicine, Emory University, Atlanta, GA 30322, USA.
Jesse T Jacob: School of Medicine, Emory University, Atlanta, GA 30322, USA. ORCID
I King Jordan: School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
David S Weiss: Emory Vaccine Center, Atlanta, GA 30317, USA.

PMID: 33227907 DOI: 10.3390/antibiotics9110825

Colistin is an important last-line antibiotic to treat highly resistant infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical isolate with a deletion of , a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in .

CRE Enterobacter colistin

J Infect Dis. 2017 Feb 15;215(suppl_1):S28-S36 [PMID: 28375512]
PLoS One. 2010 Oct 08;5(10):e13244 [PMID: 20949038]
Microb Drug Resist. 2018 Oct;24(8):1117-1120 [PMID: 29768099]
Int J Antimicrob Agents. 2020 Apr;55(4):105930 [PMID: 32130981]
Antimicrob Agents Chemother. 2015 May;59(5):2898-900 [PMID: 25691629]
J Antimicrob Chemother. 2015 Jan;70(1):75-80 [PMID: 25190723]
Antimicrob Agents Chemother. 2020 May 21;64(6): [PMID: 32253218]
J Bacteriol. 2010 May;192(9):2463-4 [PMID: 20207761]
Mol Microbiol. 2019 Jun;111(6):1604-1616 [PMID: 30873646]
Antimicrob Agents Chemother. 2015 Oct 12;60(1):609-12 [PMID: 26459897]
J Antimicrob Chemother. 2018 Jun 1;73(6):1604-1610 [PMID: 29514208]
Infect Control Hosp Epidemiol. 2019 Jan;40(1):112-113 [PMID: 30463634]
Sci Rep. 2016 May 06;6:25543 [PMID: 27150578]
N Engl J Med. 2014 Mar 27;370(13):1198-208 [PMID: 24670166]
Curr Opin Microbiol. 2014 Feb;17:106-13 [PMID: 24531506]
Antimicrob Agents Chemother. 2014 Oct;58(10):5696-703 [PMID: 25022583]
Mol Microbiol. 2016 Nov;102(3):430-445 [PMID: 27447896]
Genome Biol. 2004;5(2):R12 [PMID: 14759262]
PLoS Genet. 2009 Dec;5(12):e1000788 [PMID: 20041203]
Mol Syst Biol. 2006;2:2006.0008 [PMID: 16738554]
Nat Microbiol. 2016 May 09;1(6):16053 [PMID: 27572838]
Nat Microbiol. 2018 May;3(5):563-569 [PMID: 29693659]
J Glob Antimicrob Resist. 2020 Jun;21:386-390 [PMID: 31838239]
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [PMID: 10829079]
Int J Mol Sci. 2019 Apr 10;20(7): [PMID: 30974906]
J Bacteriol. 1995 Aug;177(15):4364-71 [PMID: 7543474]
J Bacteriol. 2001 Mar;183(6):1835-42 [PMID: 11222580]
J Antimicrob Chemother. 2015 Aug;70(8):2261-70 [PMID: 26017037]
Antimicrob Agents Chemother. 2014;58(1):518-26 [PMID: 24189257]

P51 OD011132/NIH HHS
R01 AI141883/NIAID NIH HHS
David S. Weiss/Burroughs Wellcome Fund
AI141883/NIH HHS

Journal Article

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