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Cell regeneration (London, England)
Dec 01, 2020;9 (1): 20.

Mesenchymal stem cell as a novel approach to systemic sclerosis; current status and future perspectives.

Mina Abedi, Sepideh Alavi-Moghadam, Moloud Payab, Parisa Goodarzi, Fereshteh Mohamadi-Jahani, Forough Azam Sayahpour, Bagher Larijani, Babak Arjmand
Author Information
  1. Mina Abedi: Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. ORCID
  2. Sepideh Alavi-Moghadam: Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  3. Moloud Payab: Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. ORCID
  4. Parisa Goodarzi: Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
  5. Fereshteh Mohamadi-Jahani: Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
  6. Forough Azam Sayahpour: Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
  7. Bagher Larijani: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical sciences, Tehran, Iran. ORCID
  8. Babak Arjmand: Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. barjmand@sina.tums.ac.ir. ORCID
PMID: 33258056 DOI: 10.1186/s13619-020-00058-0

Abstract

Systemic sclerosis is a rare chronic autoimmune disease with extensive microvascular injury, damage of endothelial cells, activation of immune responses, and progression of tissue fibrosis in the skin and various internal organs. According to epidemiological data, women's populations are more susceptible to systemic sclerosis than men. Until now, various therapeutic options are employed to manage the symptoms of the disease. Since stem cell-based treatments have developed as a novel approach to rescue from several autoimmune diseases, it seems that stem cells, especially mesenchymal stem cells as a powerful regenerative tool can also be advantageous for systemic sclerosis treatment via their remarkable properties including immunomodulatory and anti-fibrotic effects. Accordingly, we discuss the contemporary status and future perspectives of mesenchymal stem cell transplantation for systemic sclerosis.

Keywords

Anti- fibrotic effect Autoimmune disease Cell therapy Immunomodulation Mesenchymal stem cells Regenerative medicine Systemic sclerosis

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