Properties of the Vascular Networks in Malignant Tumors.

Juan Carlos Chimal-Eguía, Erandi Castillo-Montiel, Ricardo T Paez-Hernández
Author Information
  1. Juan Carlos Chimal-Eguía: Centro de Investigación en Computación del Instituto Politécnico Nacional, Av. Miguel Othon de Mendizabal s/n. Col. La Escalera, Ciudad de México CP 07738, Mexico.
  2. Erandi Castillo-Montiel: Department of Técnologias WEB, Instituto Politécnico Nacional (IPN) - Centro Nacional de Cálculo (CENAC), Av. Luis Enrique Erro S/N, Unidad Profesional Adolfo López Mateos, Zacatenco, Gustavo A. Madero, Ciudad de México CP 07738, Mexico. ORCID
  3. Ricardo T Paez-Hernández: Área de Física de Procesos Irreversibles, Departamento de Ciencias Básicas, Universidad Autónoma Metropolitana, U-Azcapotzalco, Av. San Pablo 180, Col.Reynosa, Ciudad de México CP 02200, Mexico.

Abstract

This work presents an analysis for real and synthetic angiogenic networks using a tomography image that obtains a portrait of a vascular network. After the image conversion into a binary format it is possible to measure various network properties, which includes the average path length, the clustering coefficient, the degree distribution and the fractal dimension. When comparing the observed properties with that produced by the Invasion Percolation algorithm (IPA), we observe that there exist differences between the properties obtained by the real and the synthetic networks produced by the IPA algorithm. Taking into account the former, a new algorithm which models the expansion of an angiogenic network through randomly heuristic rules is proposed. When comparing this new algorithm with the real networks it is observed that now both share some properties. Once creating synthetic networks, we prove the robustness of the network by subjecting the original angiogenic and the synthetic networks to the removal of the most connected nodes, and see to what extent the properties changed. Using this concept of robustness, in a very naive fashion it is possible to launch a hypothetical proposal for a therapeutic treatment based on the robustness of the network.

Keywords

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Grants

  1. 20196225/Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional

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