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International journal of molecular sciences
Dec 05, 2020;21 (23):

Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses.

Dörthe Masemann, Stephan Ludwig, Yvonne Boergeling
Author Information
  1. Dörthe Masemann: Institute of Virology Muenster, University of Muenster, 48149 Muenster, Germany.
  2. Stephan Ludwig: Institute of Virology Muenster, University of Muenster, 48149 Muenster, Germany. ORCID
  3. Yvonne Boergeling: Institute of Virology Muenster, University of Muenster, 48149 Muenster, Germany.
PMID: 33291453 DOI: 10.3390/ijms21239289

Abstract

Medical research is changing into direction of precision therapy, thus, sophisticated preclinical models are urgently needed. In human pathogenic virus research, the major technical hurdle is not only to translate discoveries from animals to treatments of humans, but also to overcome the problem of interspecies differences with regard to productive infections and comparable disease development. Transgenic mice provide a basis for research of disease pathogenesis after infection with human-specific viruses. Today, humanized mice can be found at the very heart of this forefront of medical research allowing for recapitulation of disease pathogenesis and drug mechanisms in humans. This review discusses progress in the development and use of transgenic mice for the study of virus-induced human diseases towards identification of new drug innovations to treat and control human pathogenic infectious diseases.

Keywords

human pathogenic viruses humanized mouse models transgenic mice

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Grants

  1. SFB1009B02 and CRU342 P6/Deutsche Forschungsgemeinschaft
  2. Lud2/008/17 and Lud-A/013/21/Interdisciplinary Center of Medical Research

MeSH Term

Animals
Disease Models, Animal
Gene Expression Regulation, Viral
Host-Pathogen Interactions
Humans
Immune System
Mice, Transgenic
Organ Specificity
Receptors, Cell Surface
Viral Tropism
Virus Diseases
Virus Replication

Chemicals

Receptors, Cell Surface
Journal Article Review
Article has an altmetric score of 4

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