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Revista espanola de geriatria y gerontologia
2021 Mar-Apr;56 (2): 75-80.

[Prevalence of SARS-CoV-2 coronavirus infection in patients and professional staff at a medium or long-stay hospital in Spain].

Luis Antonio Moreno Borraz, Mercedes Giménez López, Patricia Carrera Lasfuentes, Emilio González Pérez, Concepción Ortíz Domingo, José Luis Bonafonte Marteles, Carmen Vicente Gaspar, Francisco Amorós de la Nieta, Alejandro Sastre Heres, Ángel Luis García Forcada, María Pilar Serrano Herrero, Silvia Fernández Doblado, María Carmen Espinosa Val, María Mar Fernández Adarve, Adriana Narvión Carriquiri, Fernando Arto Maza, Marta Barea Gil, Irene Aznar Vázquez, Raquel Sisas Rubio, Raquel González Tejedor, Evelyn Florentín Ostáriz, Consuelo López Santed, Ana Rosa Molina Morales, Sara Parrilla Binué, Javier Pérez Sans, Mercedes García Mena, Belén Moragrega Cardona, Marta Luzón Alonso, Francisco Díaz Mora, Juan Carlos Gil Acebes, Yolanda Rubio Morilla, Rosa Lou Lou, Rosa Blanca Zabala Lahoz, Ana Coarasa Lirón de Robles
Author Information
  1. Luis Antonio Moreno Borraz: Laboratorio de Microbiología, Hospital San Juan de Dios, Zaragoza, España. Electronic address: lamoreno@ohsjd.es.
  2. Mercedes Giménez López: Unidad de Docencia, Investigación, Hospital San Juan de Dios, Zaragoza, España.
  3. Patricia Carrera Lasfuentes: CIBER de Enfermedades Hepáticas y Digestivas (CIBEREHD) , Zaragoza, España.
  4. Emilio González Pérez: Geriatría, Hospital San Juan de Dios, Zaragoza, España.
  5. Concepción Ortíz Domingo: Geriatría, Hospital San Juan de Dios, Zaragoza, España.
  6. José Luis Bonafonte Marteles: Geriatría, Hospital San Juan de Dios, Zaragoza, España.
  7. Carmen Vicente Gaspar: Gerencia, Hospital San Juan de Dios, Zaragoza, España.
  8. Francisco Amorós de la Nieta: Dirección, Hospital San Juan de Dios, Zaragoza, España.
  9. Alejandro Sastre Heres: Farmacia, Hospital San Juan de Dios, Zaragoza, España.
  10. Ángel Luis García Forcada: Medicina Interna, Hospital San Juan de Dios, Zaragoza, España.
  11. María Pilar Serrano Herrero: Medicina Interna, Hospital San Juan de Dios, Zaragoza, España.
  12. Silvia Fernández Doblado: Geriatría, Hospital San Juan de Dios, Zaragoza, España.
  13. María Carmen Espinosa Val: Geriatría, Hospital San Juan de Dios, Zaragoza, España.
  14. María Mar Fernández Adarve: Servicio de Admisión, Hospital San Juan de Dios, Zaragoza, España.
  15. Adriana Narvión Carriquiri: Geriatría, Hospital San Juan de Dios, Zaragoza, España.
  16. Fernando Arto Maza: Geriatría, Hospital San Juan de Dios, Zaragoza, España.
  17. Marta Barea Gil: Enfermería, Hospital San Juan de Dios, Zaragoza, España.
  18. Irene Aznar Vázquez: Enfermería, Hospital San Juan de Dios, Zaragoza, España.
  19. Raquel Sisas Rubio: Enfermería, Hospital San Juan de Dios, Zaragoza, España.
  20. Raquel González Tejedor: Enfermería, Hospital San Juan de Dios, Zaragoza, España.
  21. Evelyn Florentín Ostáriz: Enfermería, Hospital San Juan de Dios, Zaragoza, España.
  22. Consuelo López Santed: Enfermería, Hospital San Juan de Dios, Zaragoza, España.
  23. Ana Rosa Molina Morales: Enfermería, Hospital San Juan de Dios, Zaragoza, España.
  24. Sara Parrilla Binué: Enfermería, Hospital San Juan de Dios, Zaragoza, España.
  25. Javier Pérez Sans: Unidad de riesgos Laborables, Hospital San Juan de Dios, Zaragoza, España.
  26. Mercedes García Mena: Unidad de Hemodiálisis, Hospital San Juan de Dios, Zaragoza, España.
  27. Belén Moragrega Cardona: Unidad de Hemodiálisis, Hospital San Juan de Dios, Zaragoza, España.
  28. Marta Luzón Alonso: Unidad de Hemodiálisis, Hospital San Juan de Dios, Zaragoza, España.
  29. Francisco Díaz Mora: Medicina MF y C, Hospital San Juan de Dios, Zaragoza, España.
  30. Juan Carlos Gil Acebes: Medicina MF y C, Hospital San Juan de Dios, Zaragoza, España.
  31. Yolanda Rubio Morilla: Servicio de Admisión, Hospital San Juan de Dios, Zaragoza, España.
  32. Rosa Lou Lou: Medicina MF y C, Hospital San Juan de Dios, Zaragoza, España.
  33. Rosa Blanca Zabala Lahoz: Medicina MF y C, Hospital San Juan de Dios, Zaragoza, España.
  34. Ana Coarasa Lirón de Robles: Unidad de Neurorrehabilitación, Hospital San Juan de Dios, Zaragoza, España.
PMID: 33308845 DOI: 10.1016/j.regg.2020.10.005

Abstract

BACKGROUND AND GOALS: The aim of the study is to know the prevalence of SARS-CoV-2 infection in patients and professional staff of a medium or long-stay hospital during the peak period of the pandemic in Spain, spring 2020.
MATERIAL AND METHODS: At the end of February 2020, we developed at the hospital a strategy to diagnose the SARS-CoV-2 infection consisting of complementing the realization of PCR tests at real time with a quick technique of lateral flow immunochromatography to detect IgG and IgM antibodies against the virus. We also developed a protocol to realize those diagnostic tests and considered an infection (current or past) a positive result in any of the above tests. We included 524 participants in the study (230 patients and 294 hospital staff), and divided them into hospital patients and Hemodialysis outpatients. Furthermore, we divided the hospital staff into healthcare and non-healthcare staff. The documented period was from March, 20 to April, 21, 2020.
RESULTS: 26 out of 230 patients tested positive in any of the diagnostic techniques (PCR, antibodies IgG, IgM) with a 11.30% prevalence. According to patients groups, we got a 14.38% prevalence in hospital patients vs. 5.95% in outpatients, with a significantly higher risk in admitted patients after adjustment for age and gender (OR=3,309, 95%CI: 1,154-9,495). 24 out of 294 hospital staff tested positive in any of the diagnostic techniques, with a 8.16% prevalence. According to the groups, we got a 8.91% prevalence in healthcare staff vs. 4.26% in non-healthcare staff. Thus, we do not see any statistically significant differences between hospital staff and patients as far as prevalence is concerned (P=0,391), (OR=2,200, 95%CI: 0,500-9,689).
CONCLUSIONS: The result of the study was a quite low prevalence rate of SARS-CoV-2 infection, in both patients and hospital staff, being the hospital patients' prevalence rate higher than the outpatients', and the healthcare staff higher than the non-healthcare's. Combining PCR tests (gold standard) with antibodies tests proved useful as a diagnostic strategy.

Keywords

Antibodies Anticuerpos Hospital media y larga estancia Medium or long-stay hospital PCR Prevalence Prevalencia SARS-CoV-2

References

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  2. Yi Chuan. 2020 Feb 20;42(2):212-221 [PMID: 32102777]
  3. Nat Commun. 2020 Jul 8;11(1):3500 [PMID: 32641730]
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MeSH Term

Adult
Aged
Aged, 80 and over
COVID-19
Female
Hospitalization
Hospitals
Humans
Male
Middle Aged
Occupational Diseases
Personnel, Hospital
Prevalence
Spain
Young Adult
Journal Article
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0hospitalstaffpatientsprevalenceSARS-CoV-2infectiontestsPCRdiagnosticstudylong-stay2020antibodiespositivehealthcarehigherANDprofessionalmediumperioddevelopedstrategyIgGIgMresult230294dividedoutpatientsnon-healthcaretestedtechniquesAccordinggroupsgotvs95%CI:8rateBACKGROUNDGOALS:aimknowpeakpandemicSpainspringMATERIALMETHODS:endFebruarydiagnoseconsistingcomplementingrealizationrealtimequicktechniquelateralflowimmunochromatographydetectvirusalsoprotocolrealizeconsideredcurrentpastincluded524participantsHemodialysisFurthermoredocumentedMarch20April21RESULTS:261130%1438%595%significantlyriskadmittedadjustmentagegenderOR=33091154-94952416%91%426%ThusseestatisticallysignificantdifferencesfarconcernedP=0391OR=22000500-9689CONCLUSIONS:quitelowpatients'outpatients'non-healthcare'sCombininggoldstandardproveduseful[PrevalencecoronavirusSpain]AntibodiesAnticuerposHospitalmediaylargaestanciaMediumPrevalencePrevalencia

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