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Trends in genetics : TIG
03, 2021;37 (3): 203-204.

Using Genetics To Dissect SARS-CoV-2 Infection.

Patrick Brest, Baharia Mograbi, Paul Hofman, Gerard Milano
Author Information
  1. Patrick Brest: Université Côte d'Azur, Institute of Research on Cancer and Aging in Nice (IRCAN), Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Hospitalo-Universitaire (FHU) OncoAge, F-06189 Nice, France. Electronic address: Patrick.BREST@univ-cotedazur.fr.
  2. Baharia Mograbi: Université Côte d'Azur, Institute of Research on Cancer and Aging in Nice (IRCAN), Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Hospitalo-Universitaire (FHU) OncoAge, F-06189 Nice, France.
  3. Paul Hofman: Université Côte d'Azur, Institute of Research on Cancer and Aging in Nice (IRCAN), Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Hospitalo-Universitaire (FHU) OncoAge, F-06189 Nice, France; Université Côte d'Azur, Centre Hospitalier Universitaire (CHU) de Nice, Laboratory of Clinical and Experimental Pathology, FHU OncoAge, Hospital-Integrated Biobank (BB-0033-00025), F-06001 Nice, France.
  4. Gerard Milano: Université Côte d'Azur, Centre Antoine Lacassagne, Unité Propre de Recherche 7497 Université Côte d'Azur, F-06100 Nice, France. Electronic address: gerard.milano@nice.unicancer.fr.
PMID: 33309104 DOI: 10.1016/j.tig.2020.11.007

Abstract

To uncover the key cellular pathways associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity, Daniloski and coworkers used CRISPR-based whole-genome screening. Their results could propose new or repositioned drugs for the ongoing fight against COVID-19.

References

  1. Trends Genet. 2020 Nov;36(11):813-815 [PMID: 32828550]
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MeSH Term

Angiotensin-Converting Enzyme 2
COVID-19
CRISPR-Cas Systems
Gene Editing
Gene Expression
Genome, Viral
Genome-Wide Association Study
Humans
RNA Interference
SARS-CoV-2

Chemicals

ACE2 protein, human
Angiotensin-Converting Enzyme 2
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 15

Word Cloud

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