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AAPS PharmSciTech
Jan 05, 2021;22 (1): 24.

pH-Independent Dissolution and Enhanced Oral Bioavailability of Aripiprazole-Loaded Solid Self-microemulsifying Drug Delivery System.

Sundar Mahajan, Dilpreet Singh, Rashi Sharma, Gurdeep Singh, Neena Bedi
Author Information
  1. Sundar Mahajan: Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India.
  2. Dilpreet Singh: Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India.
  3. Rashi Sharma: Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India.
  4. Gurdeep Singh: Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India.
  5. Neena Bedi: Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India. neena.pharma@gndu.ac.in.
PMID: 33400035 DOI: 10.1208/s12249-020-01882-y

Abstract

The present study pursued the systematic development of a stable solid self-emulsifying drug delivery system (SMEDDS) of an atypical antipsychotic drug, aripiprazole (APZ), which exhibits poor aqueous solubility and undergoes extensive p-glycoprotein efflux and hepatic metabolism. Liquid SMEDDS excipients were selected on the basis of solubility studies, and the optimum ratio of surfactant/co-surfactant was determined using pseudo-ternary phase diagrams. The prepared formulations were subjected to in vitro characterization studies to facilitate the selection of optimum liquid SMEDD formulation containing 30% Labrafil® M 1944 CS, 46.7% Cremophor® EL and 23.3% PEG 400 which were further subjected to solidification using maltodextrin as a hydrophilic carrier. The optimized solid SMEDDS was extensively evaluated for stability under accelerated conditions, dissolution at various pH and pharmacokinetic profile. Solid-state attributes of the optimized solid SMEDDS indicated a marked reduction in crystallinity of APZ and uniform adsorption of liquid SMEDDS. Stability study of the solid SMEDDS demonstrated that the developed formulation retained its stability during the accelerated storage conditions. Both the optimized liquid and solid SMEDDS exhibited enhanced dissolution rate which was furthermore independent of the pH of the dissolution medium. Oral bioavailability studies in Sprague-Dawley rats confirmed quicker and greater extent of absorption with solid SMEDDS as evident from the significant reduction in T in case of solid SMEDDS (0.83 ± 0.12 h) as compared with commercial tablet (3.33 ± 0.94 h). The results of the present investigation indicated the development of a stable solid SMEDDS formulation of APZ with enhanced dissolution and absorption attributes.

Keywords

SMEDDS aripiprazole microemulsion self-emulsifying drug delivery system solubility enhancement

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MeSH Term

Administration, Oral
Animals
Aripiprazole
Biological Availability
Drug Delivery Systems
Drug Liberation
Emulsions
Female
Hydrogen-Ion Concentration
Rats
Rats, Sprague-Dawley

Chemicals

Emulsions
Aripiprazole
Journal Article

Word Cloud

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