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International journal of molecular sciences
Jan 01, 2021;22 (1):

On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors.

Mariangela Pucci, Elizabeta Zaplatic, Maria Vittoria Micioni Di Bonaventura, Emanuela Micioni Di Bonaventura, Paolo De Cristofaro, Mauro Maccarrone, Carlo Cifani, Claudio D'Addario
Author Information
  1. Mariangela Pucci: Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, Italy. ORCID
  2. Elizabeta Zaplatic: Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, Italy.
  3. Maria Vittoria Micioni Di Bonaventura: Pharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino MC, Italy. ORCID
  4. Emanuela Micioni Di Bonaventura: Pharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino MC, Italy. ORCID
  5. Paolo De Cristofaro: Clinical Endocrinology and Metabolism Outpatient Clinic, 64021 Giulianova TE, Italy.
  6. Mauro Maccarrone: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila AQ, Italy. ORCID
  7. Carlo Cifani: Pharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino MC, Italy. ORCID
  8. Claudio D'Addario: Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, Italy.
PMID: 33401515 DOI: 10.3390/ijms22010398

Abstract

Different neuromodulatory systems are involved in long-term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies.

Keywords

eating behaviors food intake transcriptional regulation type-1 cannabinoid receptor gene

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Grants

  1. 713714/Marie Skłodowska-Curie grant agreement no. 713714 (Rep-Eat - H2020-MSCACOFUND-2015

MeSH Term

Animals
Feeding Behavior
Gene Expression Regulation
Humans
Mice
Promoter Regions, Genetic
Rats
Receptor, Cannabinoid, CB1
Transcription, Genetic

Chemicals

CNR1 protein, human
CNR1 protein, mouse
Cnr1 protein, rat
Receptor, Cannabinoid, CB1
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0type-1cannabinoidrolegeneeatingreceptorfoodintakebehaviorstranscriptionalregulationDifferentneuromodulatorysystemsinvolvedlong-termenergybalancebodyweightamongevidenceshowsendocannabinoidsystemparticularactivationplayskeyreviewcurrentliteraturefocusingencodingreceptorsCNSmodulationexpressionspecificpointimportanceinvestigateenvironmentalcuesmightdevelopmentobesitywelldisordersorderpreventtreatpathologiesRoleCentralType-1CannabinoidReceptorGeneRegulationFoodIntakeEatingBehaviors

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