Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont .
Noel M Lacerna, Cydee Marie V Ramones, Jose Miguel D Robes, Myra Ruth D Picart, Jortan O Tun, Bailey W Miller, Margo G Haygood, Eric W Schmidt, Lilibeth A Salvador-Reyes, Gisela P Concepcion
Author Information
Noel M Lacerna: The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
Cydee Marie V Ramones: The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
Jose Miguel D Robes: The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
Myra Ruth D Picart: The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
Jortan O Tun: The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
Bailey W Miller: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA. ORCID
Margo G Haygood: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
Eric W Schmidt: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
Lilibeth A Salvador-Reyes: The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines. ORCID
Gisela P Concepcion: The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
The bioactivity-guided purification of the culture broth of the shipworm endosymbiont strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (), and two previously described Oxylipins (-). turneroic acid () is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds - inhibited bacterial biofilm formation in , while only showed antimicrobial activity against planktonic . . Comparison of the bioactivity of - with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition.
