Risk-Based Decision Making: A Systematic Scoping Review of Animal Models and a Pilot Study on the Effects of Sleep Deprivation in Rats.
Cathalijn H C Leenaars, Stevie Van der Mierden, Ruud N J M A Joosten, Marnix A Van der Weide, Mischa Schirris, Maurice Dematteis, Franck L B Meijboom, Matthijs G P Feenstra, Andr�� Bleich
Author Information
Cathalijn H C Leenaars: Institute for Laboratory Animal Science, Hannover Medical School, 30625 Hannover, Germany.
Stevie Van der Mierden: Institute for Laboratory Animal Science, Hannover Medical School, 30625 Hannover, Germany.
Ruud N J M A Joosten: Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, 1000 Amsterdam, The Netherlands.
Marnix A Van der Weide: Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, 1000 Amsterdam, The Netherlands.
Mischa Schirris: Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, 1000 Amsterdam, The Netherlands.
Maurice Dematteis: Department of Addiction Medicine, Grenobles Alpes University Hospital, Faculty of Medicine, Grenoble Alpes University, 38400 Grenoble, France.
Franck L B Meijboom: Unit Animals in Science and Society, Population Health Sciences, Utrecht University, 3500 Utrecht, The Netherlands. ORCID
Matthijs G P Feenstra: Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, 1000 Amsterdam, The Netherlands.
Andr�� Bleich: Institute for Laboratory Animal Science, Hannover Medical School, 30625 Hannover, Germany.
Animals, including humans, frequently make decisions involving risk or uncertainty. Different strategies in these decisions can be advantageous depending the circumstances. Short sleep duration seems to be associated with more risky decisions in humans. Animal models for risk-based decision making can increase mechanistic understanding, but very little data is available concerning the effects of sleep. We combined primary- and meta-research to explore the relationship between sleep and risk-based decision making in animals. Our first objective was to create an overview of the available animal models for risky decision making. We performed a systematic scoping review. Our searches in Pubmed and Psychinfo retrieved 712 references, of which 235 were included. Animal models for risk-based decision making have been described for rodents, non-human primates, birds, pigs and honey-bees. We discuss task designs and model validity. Our second objective was to apply this knowledge and perform a pilot study on the effect of sleep deprivation. We trained and tested male Wistar rats on a probability discounting task; a "safe" lever always resulted in 1 reward, a "risky" lever resulted in 4 or no rewards. rats adapted their preferences to variations in reward probabilities ( < 0.001), but 12 h of sleep deprivation during the light phase did not clearly alter risk preference ( = 0.21).
