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05, 2021;557 70-85.

On the road to ending the COVID-19 pandemic: Are we there yet?

James Brett Case, Emma S Winkler, John M Errico, Michael S Diamond
Author Information
  1. James Brett Case: Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  2. Emma S Winkler: Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA; Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  3. John M Errico: Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  4. Michael S Diamond: Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA; Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: diamond@wusm.wustl.edu.
PMID: 33676349 DOI: 10.1016/j.virol.2021.02.003

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged into the human population in late 2019 and caused the global COVID-19 pandemic. SARS-CoV-2 has spread to more than 215 countries and infected many millions of people. Despite the introduction of numerous governmental and public health measures to control disease spread, infections continue at an unabated pace, suggesting that effective vaccines and antiviral drugs will be required to curtail disease, end the pandemic, and restore societal norms. Here, we review the current developments in antibody and vaccine countermeasures to limit or prevent disease.

Keywords

Antibody COVID-19 Immunity Pathogenesis Protection SARS-CoV-2 Therapy Vaccines

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Grants

  1. F30 AI152327/NIAID NIH HHS
  2. R01 AI157155/NIAID NIH HHS

MeSH Term

Animals
Antibodies, Viral
COVID-19
COVID-19 Vaccines
Clinical Trials as Topic
Disease Models, Animal
Genetic Vectors
Humans
Immunity, Innate
Immunization, Passive
Immunogenicity, Vaccine
Pandemics
Patient Safety
SARS-CoV-2
Vaccines, Attenuated
Vaccines, DNA
Vaccines, Subunit
Vaccines, Virus-Like Particle
COVID-19 Serotherapy

Chemicals

Antibodies, Viral
COVID-19 Vaccines
Vaccines, Attenuated
Vaccines, DNA
Vaccines, Subunit
Vaccines, Virus-Like Particle
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 27

Word Cloud

Created with Highcharts 10.0.0SARS-CoV-2COVID-19diseasepandemicspreadSevereacuterespiratorysyndromecoronavirus2emergedhumanpopulationlate2019causedglobal215countriesinfectedmanymillionspeopleDespiteintroductionnumerousgovernmentalpublichealthmeasurescontrolinfectionscontinueunabatedpacesuggestingeffectivevaccinesantiviraldrugswillrequiredcurtailendrestoresocietalnormsreviewcurrentdevelopmentsantibodyvaccinecountermeasureslimitpreventroadendingpandemic:yet?AntibodyImmunityPathogenesisProtectionTherapyVaccines

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