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Folia microbiologica
Apr, 2021;66 (2): 285-291.

Antibacterial activity of selected invertebrate species.

Salwa Mansur Ali, Ruqaiyayh Siddiqui, Kuppusamy A Sagathevan, Naveed Ahmed Khan
Author Information
  1. Salwa Mansur Ali: Department of Biological Sciences, Sunway University, Bandar Sunway, Malaysia.
  2. Ruqaiyayh Siddiqui: College of Arts and Sciences, American University of Sharjah, Sharjah, UAE.
  3. Kuppusamy A Sagathevan: Department of Biological Sciences, Sunway University, Bandar Sunway, Malaysia.
  4. Naveed Ahmed Khan: Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, UAE. naveed5438@gmail.com. ORCID
PMID: 33704690 DOI: 10.1007/s12223-021-00860-6

Abstract

The evolution of multiple-drug resistant bacteria is contributing to the global antimicrobial crisis, hence driving us to search for novel antimicrobial(s). Among animals, invertebrates represent up to 80% of all known species suggesting their wide distribution. Despite their ubiquitous and plentiful nature, they have been largely unexplored as potential source of antibacterials. In this study, we selected a broad range of invertebrates from terrestrial and marine environments and tested their lysates for antibacterial activity against methicillin-resistant Staphylococcus aereus (MRSA) and neuropathogenic Escherichia coli K1. Cockroaches, centipedes, tarantulas, prawns, lobster, and mud crabs showed antibacterial activity with selected lysates exhibiting more than 90% bactericidal effects. The red-headed centipede's hemolymph showed 90% and 50% bacteriostatic activity against MRSA and E. coli K1, respectively. Tarantula's body extracts exhibited antibacterial activity against MRSA and E. coli K1. Gut extracts of tiger prawn exhibited more than 90% bacteriostatic activity against both bacteria. The selected lobster and mud crab extract exhibited up to 90% growth inhibitory activity against MRSA. Overall, these results showed that selected invertebrates are an untapped source of broad-spectrum antibacterial activity and suggest the presence of biologically active molecules.

Keywords

Antibacterial Drug resistant bacteria Insects Invertebrates

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MeSH Term

Animals
Anti-Bacterial Agents
Escherichia coli
Invertebrates
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests

Chemicals

Anti-Bacterial Agents
Journal Article

Word Cloud

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