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Signal transduction and targeted therapy
03 11, 2021;6 (1): 119.

SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response.

Guijie Guo, Ming Gao, Xiaochen Gao, Bibo Zhu, Jinzhou Huang, Kuntian Luo, Yong Zhang, Jie Sun, Min Deng, Zhenkun Lou
Author Information
  1. Guijie Guo: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  2. Ming Gao: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  3. Xiaochen Gao: Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
  4. Bibo Zhu: Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
  5. Jinzhou Huang: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  6. Kuntian Luo: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  7. Yong Zhang: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  8. Jie Sun: Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
  9. Min Deng: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  10. Zhenkun Lou: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. lou.zhenkun@mayo.edu. ORCID
PMID: 33707416 DOI: 10.1038/s41392-021-00509-3

Abstract

No abstract text available.

References

  1. PLoS Pathog. 2017 Nov 10;13(11):e1006720 [PMID: 29125880]
  2. Lancet. 2020 Feb 15;395(10223):497-506 [PMID: 31986264]
  3. Cell. 2020 May 28;181(5):1036-1045.e9 [PMID: 32416070]
  4. Science. 2015 Mar 13;347(6227):aaa2630 [PMID: 25636800]
  5. Nat Commun. 2017 May 23;8:15534 [PMID: 28534493]

Grants

  1. R01 CA203971/NCI NIH HHS
  2. R01 AG047156/NIA NIH HHS
  3. R01 AI147394/NIAID NIH HHS
  4. R01 AI112844/NIAID NIH HHS
  5. P30 CA015083/NCI NIH HHS

MeSH Term

A549 Cells
COVID-19
HEK293 Cells
Humans
Immunity, Innate
SARS-CoV-2
Ubiquitin-Specific Proteases
Viral Nonstructural Proteins

Chemicals

Viral Nonstructural Proteins
USP13 protein, human
Ubiquitin-Specific Proteases
Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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