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Cancer gene therapy
03, 2022;29 (3-4): 253-263.

Glioma pathogenesis-related protein 1 performs dual functions in tumor cells.

Junjie Wang, Zeyu Li, Fenfen Yin, Rui Zhang, Ying Zhang, Zhengxin Wang, Xiumei Sheng
Author Information
  1. Junjie Wang: Department of Pathophysiology, Jiangsu University School of Medicine, Zhenjiang, 212013, Jiangsu, China.
  2. Zeyu Li: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine, Zhenjiang, 212013, Jiangsu, China.
  3. Fenfen Yin: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine, Zhenjiang, 212013, Jiangsu, China.
  4. Rui Zhang: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine, Zhenjiang, 212013, Jiangsu, China. ORCID
  5. Ying Zhang: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine, Zhenjiang, 212013, Jiangsu, China. ORCID
  6. Zhengxin Wang: The Center for Cancer Research and Therapeutic Development, Department of Biological Sciences, Clark Atlanta University, Atlanta, GA, 30314, USA. zwang@cau.edu. ORCID
  7. Xiumei Sheng: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine, Zhenjiang, 212013, Jiangsu, China. shengxiumei@ujs.edu.cn. ORCID
PMID: 33742130 DOI: 10.1038/s41417-021-00321-9

Abstract

Glioma pathogenesis-related protein 1 (GLIPR1) was identified as an oncoprotein in some cancer types including gliomas, breast cancers, melanoma cancers, and Wilms tumors, but as a tumor suppressor in some other types of cancers, such as prostate cancers, lung cancers, bladder cancers, and thyroid cancers. In gliomas, GLIPR1 promotes the migration and invasion of glioma cells by interaction with the actin polymerization regulator Neural Wiskott-Aldrich syndrome protein (N-WASP) and then abolishes the negative effects of Heterogeneous nuclear ribonuclear protein K (hnRNPK). In prostate cancers, high levels of GLIPR1 induce apoptosis and destruction of oncoproteins. In lung cancers, overexpression of GLIPR1 inhibits the growth of lung cancer cells partially through inhibiting the V-ErbB avian erythroblastic leukemia viral oncogene homolog3 (ErbB3) pathway. However, the mechanisms that GLIPR1 performs its function in other tumors still remain unclear. The tumor suppressing role of GLIPR1 has been explored to the cancer treatment. The adenoviral vector-mediated Glipr1 (AdGlipr1) gene therapy and the GLIPR1-transmembrane domain deleted (GLIPR1-ΔTM) protein therapy both showed antitumor activities and stimulated immune response in prostate cancers. Whether GLPIR1 can be used to treat other tumors is an important topic to be explored. Among which, whether GLPIR1 can be used to treat lung cancer by atomizing inhalation is the key topic we care about. If it does, this therapy has a wide application prospect and is a great progression in lung cancer treatment.

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MeSH Term

Glioma
Humans
Lung Neoplasms
Male
Membrane Proteins
Neoplasm Proteins
Nerve Tissue Proteins
Nuclear Proteins
Prostatic Neoplasms

Chemicals

GLIPR1 protein, human
Membrane Proteins
Neoplasm Proteins
Nerve Tissue Proteins
Nuclear Proteins
Journal Article Review Research Support, Non-U.S. Gov't
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Word Cloud

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