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Journal of clinical gastroenterology
03 01, 2022;56 (3): e250-e262.

Prevalence and Clinical and Endoscopic Characteristics of Cervical Inlet Patch (Heterotopic Gastric Mucosa): A Systematic Review and Meta-Analysis.

Yue Yin, Hongyu Li, Ji Feng, Kexin Zheng, Eric Yoshida, Le Wang, Yanyan Wu, Xiaozhong Guo, Xiaodong Shao, Xingshun Qi
Author Information
  1. Yue Yin: Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.
  2. Hongyu Li: Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.
  3. Ji Feng: Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.
  4. Kexin Zheng: Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.
  5. Eric Yoshida: Department of Medicine, Division of Gastroenterology, Vancouver General Hospital, Vancouver, Canada.
  6. Le Wang: Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.
  7. Yanyan Wu: Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.
  8. Xiaozhong Guo: Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.
  9. Xiaodong Shao: Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.
  10. Xingshun Qi: Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.
PMID: 33780217 DOI: 10.1097/MCG.0000000000001516

Abstract

BACKGROUND: Cervical inlet patch (CIP), also called gastric inlet patch, is a heterotopic columnar mucosal island located in the cervical esophagus, which has been under-recognized by clinicians.
AIM: We conducted a systemic review and meta-analysis to explore the prevalence and clinical and endoscopic characteristics of CIP.
MATERIALS AND METHODS: Studies were searched through the PubMed, EMBASE, and Cochrane Library databases. The prevalence of CIP with 95% confidence interval (CI) was pooled by using a random-effect model. The association of CIP with demographics, clinical presentations, and endoscopic features was evaluated by odds ratios (ORs).
RESULTS: Fifty-three studies including 932,777 patients were eligible. The pooled prevalence of CIP was 3.32% (95% CI=2.86%-3.82%). According to the endoscopic mode, the pooled prevalence of CIP was higher in studies using narrow-band imaging than in those using white light and esophageal capsule endoscopy (9.34% vs. 2.88% and 0.65%). The pooled prevalence of CIP was higher in studies where the endoscopists paid specific attention to the detection of this lesion (5.30% vs. 0.75%). CIP was significantly associated with male (OR=1.24, 95% CI=1.09-1.42, P=0.001), gastroesophageal reflux disease (OR=1.32, 95% CI=1.04-1.68, P=0.03), reflux symptoms (OR=1.44, 95% CI=1.14-1.83, P=0.002), dysphagia (OR=1.88, 95% CI=1.28-2.77, P=0.001), throat discomfort (OR=4.58, 95% CI=1.00-21.02, P=0.05), globus (OR=2.95, 95% CI=1.52-5.73, P=0.001), hoarseness (OR=4.32, 95% CI=1.91-9.78, P=0.0004), cough (OR=3.48, 95% CI=1.13-10.72, P=0.03), Barrett's esophagus (OR=2.01, 95% CI=1.37-2.94, P=0.0003), and esophagitis (OR=1.62, 95% CI=1.27-2.07, P=0.0001).
CONCLUSION: CIP appears to be common by using narrow-band imaging, especially if the endoscopists would like to pay attention to the detection of this lesion. CIP is clearly associated with acid-related symptoms and Barrett's esophagus.

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MeSH Term

Barrett Esophagus
Bays
Choristoma
Esophageal Diseases
Esophagoscopy
Gastric Mucosa
Humans
Male
Prevalence
Journal Article Meta-Analysis Systematic Review

Word Cloud

Created with Highcharts 10.0.095%CIPCI=1P=0prevalenceOR=1pooledusingesophagusendoscopicstudies001Cervicalinletpatchclinicalhighernarrow-bandimagingvs0endoscopistsattentiondetectionlesionassociatedreflux3203symptomsOR=4OR=2Barrett'sBACKGROUND:alsocalledgastricheterotopiccolumnarmucosalislandlocatedcervicalunder-recognizedcliniciansAIM:conductedsystemicreviewmeta-analysisexplorecharacteristicsMATERIALSANDMETHODS:StudiessearchedPubMedEMBASECochraneLibrarydatabasesconfidenceintervalCIrandom-effectmodelassociationdemographicspresentationsfeaturesevaluatedoddsratiosORsRESULTS:Fifty-threeincluding932777patientseligible332%CI=286%-382%Accordingmodewhitelightesophagealcapsuleendoscopy934%288%65%paidspecific530%75%significantlymale2409-142gastroesophagealdisease04-1684414-183002dysphagia8828-277throatdiscomfort5800-210205globus9552-573hoarseness91-9780004coughOR=34813-10720137-2940003esophagitis6227-2070001CONCLUSION:appearscommonespeciallylikepayclearlyacid-relatedPrevalenceClinicalEndoscopicCharacteristicsInletPatchHeterotopicGastricMucosa:SystematicReviewMeta-Analysis

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