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Techniques in coloproctology
05, 2021;25 (5): 569-577.

T2-weighted, apparent diffusion coefficient and F-FDG PET histogram analysis of rectal cancer after preoperative chemoradiotherapy.

F Crimì, R Stramare, G Spolverato, V Aldegheri, A Barison, L D'Alimonte, Q R Bao, A Spimpolo, L Albertoni, D Cecchin, C Campi, E Quaia, S Pucciarelli, P Zucchetta
Author Information
  1. F Crimì: Institute of Radiology, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
  2. R Stramare: Institute of Radiology, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
  3. G Spolverato: Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Via Nicolò Giustiniani 2, 35128, Padova, Italy. gaya.spolverato@unipd.it. ORCID
  4. V Aldegheri: Institute of Radiology, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
  5. A Barison: Institute of Radiology, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
  6. L D'Alimonte: Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Via Nicolò Giustiniani 2, 35128, Padova, Italy.
  7. Q R Bao: Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Via Nicolò Giustiniani 2, 35128, Padova, Italy. ORCID
  8. A Spimpolo: Nuclear Medicine Unit, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
  9. L Albertoni: Surgical Pathology and Cytopathology Unit, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
  10. D Cecchin: Nuclear Medicine Unit, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
  11. C Campi: Department of Mathematics "Tullio Levi-Civita", University of Padova, Padova, Italy.
  12. E Quaia: Institute of Radiology, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
  13. S Pucciarelli: Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Via Nicolò Giustiniani 2, 35128, Padova, Italy.
  14. P Zucchetta: Nuclear Medicine Unit, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
PMID: 33792823 DOI: 10.1007/s10151-021-02440-9

Abstract

BACKGROUND: The aim of our study was to investigate the correlation among T2-weighted (T2w) images, apparent diffusion coefficient (ADC) maps, F-fluorodeoxyglucose (F-FDG) positron emission tomography (PET) images, histogram analysis and the pathological response in locally advanced rectal cancer (LARC) after preoperative chemoradiotherapy (pCRT).
METHODS: patients with LARC were prospectively enrolled between February 2015 and August 2018 and underwent PET/magnetic resonance imaging (MRI). MRI included T2w and diffusion-weighted imaging (DWI)-sequences. ADC maps and PET images were matched to the T2w images. Voxel-based standardized uptake values (SUVs,) ADC and T2w-signal-intensity values were collected from the volumes of interest (VOIs) and mean, skewness and kurtosis were calculated. Spearman's correlation coefficient was applied to evaluate the correlation among the variables and tumor regression grade (TRG), T stage, N stage and fibrosis.
RESULTS: Twenty-two patients with biopsy-proven LARC in the low or mid rectum were enrolled [17 males, mean age was 69 years (range 49-85 years)]. Seven patients experienced complete regression (TRG1). A significant positive correlation was found between SUV mean values (ρ = 0.480; p = 0.037) and TRG. No other significant correlations were found.
CONCLUSIONS: Histogram analysis of SUV values is a predictor of TRG in LARC.

Keywords

Magnetic resonance imaging (MRI) Positron emission tomography (PET) Preoperative chemoradiotherapy Rectal cancer

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MeSH Term

Aged
Aged, 80 and over
Chemoradiotherapy
Diffusion Magnetic Resonance Imaging
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Neoadjuvant Therapy
Positron-Emission Tomography
Rectal Neoplasms

Chemicals

Fluorodeoxyglucose F18
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 9

Word Cloud

Created with Highcharts 10.0.0correlationimagesPETLARCvaluesT2wcoefficientADCanalysiscancerchemoradiotherapyimagingMRImeanTRGamongT2-weightedapparentdiffusionmapsF-FDGemissiontomographyhistogramrectalpreoperativeenrolledresonanceregressionstagepatientssignificantfoundSUVBACKGROUND:aimstudyinvestigateF-fluorodeoxyglucosepositronpathologicalresponselocallyadvancedpCRTMETHODS:PatientsprospectivelyFebruary2015August2018underwentPET/magneticincludeddiffusion-weightedDWI-sequencesmatchedVoxel-basedstandardizeduptakeSUVsT2w-signal-intensitycollectedvolumesinterestVOIsskewnesskurtosiscalculatedSpearman'sappliedevaluatevariablestumorgradeTNfibrosisRESULTS:Twenty-twobiopsy-provenlowmidrectum[17malesage69 yearsrange49-85 years]SevenexperiencedcompleteTRG1positiveρ = 0480p = 0037correlationsCONCLUSIONS:HistogrampredictorMagneticPositronPreoperativeRectal

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