Approaches to understanding COVID-19 and its neurological associations.

Ettore Beghi, Benedict D Michael, Tom Solomon, Erica Westenberg, Andrea S Winkler, COVID-19 Neuro Research Coalition
Author Information
  1. Ettore Beghi: Laboratorio di Malattie Neurologiche, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
  2. Benedict D Michael: Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
  3. Tom Solomon: NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, United Kingdom.
  4. Erica Westenberg: Department of Neurology, Center for Global Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ORCID
  5. Andrea S Winkler: Department of Neurology, Center for Global Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Abstract

There is an accumulating volume of research into neurological manifestations of COVID-19. However, inconsistent study designs, inadequate controls, poorly-validated tests, and differing settings, interventions, and cultural norms weaken study quality, comparability, and thus the understanding of the spectrum, burden and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the WHO, has reviewed reports of COVID-19 neurological complications and harmonised clinical measures for future research. This will facilitate well-designed studies using precise, consistent case definitions of SARS-CoV2 infection and neurological complications, with standardised forms for pooled data analyses that non-specialists can use, including in low-income settings. This article is protected by copyright. All rights reserved.

References

  1. J Neurol. 2020 Jun;267(6):1573-1576 [PMID: 32436101]
  2. Lancet Psychiatry. 2020 Oct;7(10):875-882 [PMID: 32593341]
  3. Neurocrit Care. 2020 Aug;33(1):25-34 [PMID: 32445105]
  4. SN Compr Clin Med. 2020;2(9):1377-1387 [PMID: 32838173]
  5. Can J Neurol Sci. 2021 Jan;48(1):66-76 [PMID: 32665054]
  6. Brain Commun. 2021 Jul 22;3(3):fcab168 [PMID: 34409289]
  7. J Neurol Sci. 2018 Oct 15;393:72-79 [PMID: 30121441]
  8. Seizure. 2019 Jan;64:54-58 [PMID: 30562653]
  9. Nature. 2020 Aug;584(7821):425-429 [PMID: 32604404]
  10. N Engl J Med. 2020 Jun 11;382(24):2302-2315 [PMID: 32289214]
  11. Afr J Tradit Complement Altern Med. 2009 Dec 30;7(2):162-70 [PMID: 21304629]
  12. J Neurol Sci. 2020 Jul 15;414:116884 [PMID: 32464367]
  13. Lancet Neurol. 2020 Oct;19(10):805-806 [PMID: 32949535]
  14. Clin Infect Dis. 2021 Oct 5;73(7):e2086-e2094 [PMID: 32803216]
  15. PLoS One. 2020 Nov 9;15(11):e0240784 [PMID: 33166287]
  16. Cochrane Database Syst Rev. 2020 Jun 25;6:CD013652 [PMID: 32584464]
  17. J Med Virol. 2021 Feb;93(2):1013-1022 [PMID: 32729939]
  18. Brain. 2020 Oct 1;143(10):3104-3120 [PMID: 32637987]
  19. Arq Neuropsiquiatr. 2020 Aug 03;78(8):494-500 [PMID: 32756734]
  20. Acta Neurol Scand. 2004 Apr;109(4):250-4 [PMID: 15016006]
  21. Neurology. 2021 Jan 26;96(4):e575-e586 [PMID: 33020166]
  22. BMJ. 2020 Dec 2;371:m4529 [PMID: 33268329]
  23. Neurology. 2020 Jul 14;95(2):77-84 [PMID: 32345728]
  24. Pan Afr Med J. 2020 Jul 03;35(Suppl 2):100 [PMID: 33623624]
  25. J Infect. 2020 Aug;81(2):e59-e61 [PMID: 32353384]
  26. Lancet Neurol. 2020 Jun;19(6):482-484 [PMID: 32470416]
  27. J Infect Dis. 2021 Jan 4;223(1):28-37 [PMID: 32986824]
  28. J Med Virol. 2020 Oct;92(10):1755-1756 [PMID: 32270882]
  29. Inflamm Res. 2020 Dec;69(12):1181-1189 [PMID: 32918567]
  30. Thorax. 2021 Apr;76(4):396-398 [PMID: 33172844]
  31. Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261 [PMID: 32253535]
  32. J Infect. 2020 Apr;80(4):388-393 [PMID: 32112884]
  33. Eur J Neurol. 2020 Sep;27(9):1712-1726 [PMID: 32503088]
  34. J Neurol. 2020 Aug;267(8):2179-2184 [PMID: 32458193]
  35. Eur J Neurol. 2020 Nov;27(11):e69-e72 [PMID: 32526060]
  36. Ann Indian Acad Neurol. 2020 Jul-Aug;23(4):482-486 [PMID: 33223664]
  37. Epilepsy Behav. 2010 Dec;19(4):596-601 [PMID: 20965788]
  38. Cell. 2020 Nov 12;183(4):1058-1069.e19 [PMID: 33058755]
  39. Nat Rev Neurol. 2020 Nov;16(11):636-644 [PMID: 32839585]
  40. J Neurol Sci. 2021 Apr 15;423:117283 [PMID: 33636661]
  41. Neurocrit Care. 2020 Dec;33(3):793-828 [PMID: 32948987]
  42. Epilepsy Behav. 2013 Apr;27(1):144-7 [PMID: 23416286]
  43. Radiology. 2020 Nov;297(2):E270-E273 [PMID: 32437313]
  44. Lancet Psychiatry. 2021 Feb;8(2):130-140 [PMID: 33181098]
  45. World Neurosurg. 2020 Aug;140:e360-e366 [PMID: 32442732]
  46. Neurology. 2020 Aug 18;95(7):e910-e920 [PMID: 32444493]
  47. J Neurol. 2021 May;268(5):1561-1569 [PMID: 32740766]
  48. JAMA. 2020 Aug 11;324(6):603-605 [PMID: 32644129]
  49. Neurology. 2020 Aug 25;95(8):e1060-e1070 [PMID: 32482845]
  50. Int Forum Allergy Rhinol. 2020 Jul;10(7):806-813 [PMID: 32279441]
  51. BMJ. 2020 Mar 26;368:m1091 [PMID: 32217556]
  52. Epilepsy Behav. 2011 Feb;20(2):338-43 [PMID: 21216201]
  53. Eur J Neurol. 2021 Jan;28(1):248-258 [PMID: 32853434]
  54. Lancet Neurol. 2020 Nov;19(11):919-929 [PMID: 33031735]
  55. JAMA Netw Open. 2020 Sep 1;3(9):e2021892 [PMID: 32975575]
  56. PLoS Negl Trop Dis. 2018 Jun 15;12(6):e0006588 [PMID: 29906291]
  57. BMJ. 2020 Jul 1;370:m2516 [PMID: 32611558]
  58. BMJ. 2020 Dec 17;371:m4838 [PMID: 33334862]
  59. Front Neurol. 2021 Jan 15;11:615061 [PMID: 33519693]
  60. JAMA Neurol. 2020 Aug 1;77(8):1018-1027 [PMID: 32469387]
  61. J Infect. 2020 Jun;80(6):639-645 [PMID: 32240670]
  62. Lancet Neurol. 2020 Sep;19(9):767-783 [PMID: 32622375]
  63. Neuroepidemiology. 2020;54(5):364-369 [PMID: 32610334]
  64. Int J Infect Dis. 2020 Jul;96:567-569 [PMID: 32505878]
  65. Diagnostics (Basel). 2020 Jul 04;10(7): [PMID: 32635444]
  66. JAMA Netw Open. 2020 Jul 1;3(7):e2014053 [PMID: 32609353]
  67. MMWR Morb Mortal Wkly Rep. 2020 Jul 31;69(30):993-998 [PMID: 32730238]
  68. J Neurol Sci. 2020 Jul 15;414:116923 [PMID: 32447193]
  69. Radiology. 2020 Aug;296(2):E41-E45 [PMID: 32049601]
  70. JAMA Neurol. 2020 Jun 1;77(6):683-690 [PMID: 32275288]

Grants

  1. MR/V007181/1/Medical Research Council
  2. MR/V03605X/1/Medical Research Council

Word Cloud

Created with Highcharts 10.0.0neurologicalCOVID-19complicationsresearchstudysettingsunderstandingaccumulatingvolumemanifestationsHoweverinconsistentdesignsinadequatecontrolspoorly-validatedtestsdifferinginterventionsculturalnormsweakenqualitycomparabilitythusspectrumburdenpathophysiologyThereforeglobalNeuroResearchCoalitiontogetherWHOreviewedreportsharmonisedclinicalmeasuresfuturewillfacilitatewell-designedstudiesusingpreciseconsistentcasedefinitionsSARS-CoV2infectionstandardisedformspooleddataanalysesnon-specialistscanuseincludinglow-incomearticleprotectedcopyrightrightsreservedApproachesassociations

Similar Articles

Cited By