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International journal of molecular sciences
Apr 27, 2021;22 (9):

Role of ABCA7 in Human Health and in Alzheimer's Disease.

Shiraz Dib, Jens Pahnke, Fabien Gosselet
Author Information
  1. Shiraz Dib: UR2465, LBHE-Blood-Brain Barrier Laboratory, University Artois, 62300 Lens, France.
  2. Jens Pahnke: Department of Neuro-/Pathology, University of Oslo and Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, Norway. ORCID
  3. Fabien Gosselet: UR2465, LBHE-Blood-Brain Barrier Laboratory, University Artois, 62300 Lens, France. ORCID
PMID: 33925691 DOI: 10.3390/ijms22094603

Abstract

Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer's disease (AD). This ABC transporter is now considered as an important genetic determinant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.

Keywords

ABCA7 Alzheimer’s disease Aβ peptides cholesterol phagocytosis

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Grants

  1. ANR-20-JPW2-0002-04/Agence Nationale de la Recherche (ANR)
  2. #22,2013/France Alzheimer et Maladies apparentées
  3. BQR-ABCA7/Artois University
  4. DFG 263024513/Deutsche Forschungsgemeinschaft
  5. ZS/2016/05/78617/Ministerium für Wirtschaft und Wissenschaft Sachsen-Anhalt/ Germany
  6. lzp-2018/1-0275/Latvian Council of Science
  7. 16154/Nasjonalforeningen
  8. 2019054, 2019055/HelseSØ
  9. 19008/Barnekreftforeningen
  10. TAČR TARIMAD TO100078/EEA grant/Norges grants
  11. #643417/European Union's Horizon 2020 research and innovation program

MeSH Term

ATP-Binding Cassette Transporters
Alzheimer Disease
Amyloid
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Brain
Cholesterol
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Phagocytosis
Polymorphism, Single Nucleotide

Chemicals

ABCA7 protein, human
ATP-Binding Cassette Transporters
Amyloid
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Cholesterol
Journal Article Review
Article has an altmetric score of 10

Word Cloud

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