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Journal of applied research in intellectual disabilities : JARID
Nov, 2021;34 (6): 1463-1467.

Screening of dementia indicating signs in adults with intellectual disabilities.

Maria Arvio, Nina Bjelogrlic-Laakso
Author Information
  1. Maria Arvio: Department of Neurology, Päijät-Häme Joint Municipal Authority, Hämeenlinna, Finland. ORCID
  2. Nina Bjelogrlic-Laakso: Special Services for Developmentally Disabled, Pitkäniemi, Tampere University Hospital, Tampere, Finland.
PMID: 33932064 DOI: 10.1111/jar.12888

Abstract

BACKGROUND: In intellectual disability, the cognitive delay is observed during developmental age, whereas in dementia, cognitive decline occurs during post-developmental period. So far, the risk of dementia in people with intellectual disability, excluding those with Down syndrome, is poorly known.
METHOD: We screened dementia signs in a study group of 230 adults (34-80 years of age) with the help of the British Present Psychiatric State-Learning Disabilities assessment.
RESULTS: Of the study members, 42% showed two or more signs. The overall frequency of symptoms did not differ between age groups. The number of individuals with a genetic syndrome or disease manifesting with a shortened lifespan was greater in the younger age groups when compared to the older age groups.
CONCLUSION: People with an intellectual disability represent numerous rare syndromes with comorbidities. It seems that dementia signs may affect any age groups of adults with intellectual disability.

Keywords

Present Psychiatric State-Learning Disabilities assessment (PPS-LD) ageing dementia intellectual disability memory disorders

References

  1. Arvio, M. (2016). Fragile-X syndrome-a 20-year follow-up study of male patients. Clinical Genetics, 89, 55-59. https://doi.org/10.1111/cge.12639
  2. Arvio, M., & Aaltonen, S. (2011). Kehitysvammainen potilaana. A patient with intellectual disability. Duodecim.
  3. Arvio, M., Ajasto, M., Koskinen, J., & Louhiala, L. (2013). Middle-aged people with Down syndrome receives good care in their hometowns (In Finnish). Finnish Medical Journal, 15, 1108-1112.
  4. Arvio, M., & Bjelogrlic-Laakso, N. (2017). Down Syndrome - onset age of dementia. The Journal of Alzheimer Disease & Parkinsonism, 7, 3. https://doi.org/10.4172/2161-0460
  5. Arvio, M., & Luostarinen, L. (2016). Down syndrome in adults: A 27-year follow-up of adaptive skills. Clinical Genetics, 90, 456-460. https://doi.org/10.1111/cge.12787
  6. Arvio, M., Salokivi, T., & Bjelogrlic-Laakso, N. (2016). Age at death in individuals with intellectual disabilities. Journal of Applied Research in Intellectual Disabilities, 30, 782-785. https://doi.org/10.1111/jar.12269
  7. Bjelogrlic-Laakso, N., Vuoti, H., & Storvik, M. (2020). Lääkehoito osastohoidossa olevilla kehitysvammaisilla eri autismikirjon potilailla. (Pharmacotherapy in hospitalized, intellectually disabled patients with autism spectrum disorders). Dosis, 1, 24-34.
  8. Cooper, S. (1997a). Psychiatric symptoms of dementia among elderly people with learning disabilities. International Journal of Geriatric Psychiatry, 12, 622-666.
  9. Cooper, S. A. (1997b). A population-based health survey of maladaptive behaviours associated with dementia in elderly people with learning disabilities. Journal of Intellectual Disability Research, 41, 481-487.
  10. Hof, P. R., Knabe, R., Bovier, P., & Bouras, C. (1991). Neuropathological observations in a case of autism presenting with self-injury behavior. Acta Neuropathologica, 82, 321-326. https://doi.org/10.1007/bf00308819
  11. Janicki, M. P., & Keller, S. M. (2015). Why do we need national guidelines for adults with intellectual disability and dementia? Alzheimer's & Dementia (Amsterdam, Netherlands), 1, 325-327.
  12. Lott, I. T., & Head, E. (2019). Dementia in Down syndrome: Unique insights for Alzheimer disease research. Nature Reviews Neurology, 15(3), 135-147. https://doi.org/10.1038/s41582-018-0132-6. PMID: 30733618.
  13. McCarthy, J. M., & Mullan, E. (1996). The elderly with a learning disability (mental retardation): An overview. International Psychogeriatrics, 8, 489-501. https://doi.org/10.1017/s1041610296002840
  14. Mölsä, P. (2001). Dementia and intellectual disability (in Finnish). Finnish Medical Journal, 13, 1495-1497.
  15. Sauna-aho, O., Bjelogrlic-Laakso, N., Rautava, P., & Arvio, M. (2020). Aging and cognition in men with Fragile-X syndrome. Journal of Applied Research in Intellectual Disabilities, 33, 1113-1118. https://doi.org/10.1111/jar.12733
  16. Sauna-Aho, O., Bjelogrlic-Laakso, N., Siren, A., & Arvio, M. (2018). Signs indicating dementia in Down, Williams and Fragile X syndromes. Molecular Genetics and Genomics, 6, 855-860. https://doi.org/10.1002/mgg3.430
  17. Sauna-aho, O., Siren, A., Kangasmäki, V., Bjelogrlic-Laakso, N., & Arvio, M. (2019). Cognition in adults with Williams syndrome - A 20-year follow-up study. Molecular Genetics and Genomics, 7(6), e695. https://doi.org/10.1002/mgg3.695
  18. Sheehan, R., Ali, A., & Hassiotis, A. (2014). Dementia in intellectual disability. Current Opinion in Psychiatry, 27, 143-148. https://doi.org/10.1097/YCO.0000000000000032
  19. Sheehan, R., Sinai, A., Bass, N., Blatchford, P., Bohnen, I., Bonell, S., Courtenay, K., Hassiotis, A., Markar, T., McCarthy, J., Mukherji, K., Naeem, A., Paschos, D., Perez-Achiaga, N., Sharma, V., Thomas, D., Walker, Z., & Strydom, A. (2015). Dementia diagnostic criteria in Down syndrome. International Journal of Geriatric Psychiatry, 15(30), 857-863.
  20. Silverman, W. P., Zigman, W. B., Krinsky-McHale, S. J., Ryan, R., & Schupf, N. (2013). Intellectual disability, mild cognitive impairment, and risk for dementia. Journal of Policy and Practice in Intellectual Disabilities, 1;10(3):1-12.
  21. Strydom, A., Chan, T., King, M., Hassiotis, A., & Livingston, G. (2013). Incidence of dementia in older adults with intellectual disabilities. Research in Developmental Disabilities, 34, 1881-1885.
  22. Takashima, S. (1997). Down syndrome. Current Opinion in Neurology, 10, 148-152. https://doi.org/10.1097/00019052-199704000-00013. PMID: 9146996 Review.
  23. Takenoshita, S., Terada, S., Kuwano, R., Inoue, T., Cyoju, A., Suemitsu, S., & Yamada, N. (2020). Prevalence of dementia in people with intellectual disabilities: Cross-sectional study. International Journal of Geriatric Psychiatry, 35, 414-422. https://doi.org/10.1002/gps.5258
  24. Vila-Herrero, E., Padilla-Parrado, F., Vega-Pérez, J., García-Casares, N., Heras-Pérez, J. A., & Romero-Acebal, M. (2004). Moyamoya syndrome and arterial dysplasia associated to Down syndrome. Revue Neurologique, 30(39), 943-945.

MeSH Term

Adult
Aged
Cognitive Dysfunction
Dementia
Down Syndrome
Humans
Intellectual Disability
Learning Disabilities
Journal Article
Article has an altmetric score of 1

Word Cloud

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