Xingguang Cai: Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch.
Sacha Javor: Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch.
Bee Ha Gan: Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch.
Thilo Köhler: Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Jean-Louis Reymond: Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch. ORCID
pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.
References
Chem Rev. 2019 Nov 13;119(21):11391-11441
[PMID: 31556597]
