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Mar, 2021;8 (2): 157-167.

Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma.

Dan Wang, Fengjiao Chen, Tao Zeng, Qingxia Tang, Bing Chen, Ling Chen, Yan Dong, Xiaosong Li
Author Information
  1. Dan Wang: Department of Clinical Laboratory, People's Hospital of Rongchang District, Chongqing, Rongchang 402460, PR China.
  2. Fengjiao Chen: Key Laboratory of Molecular Biology of Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, PR China.
  3. Tao Zeng: Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Province, Chengdu, 611731, PR China.
  4. Qingxia Tang: Department of Clinical Laboratory, People's Hospital of Rongchang District, Chongqing, Rongchang 402460, PR China.
  5. Bing Chen: Department of Clinical Laboratory, People's Hospital of Rongchang District, Chongqing, Rongchang 402460, PR China.
  6. Ling Chen: Key Laboratory of Molecular Biology of Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, PR China.
  7. Yan Dong: Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.
  8. Xiaosong Li: Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.
PMID: 33997162 DOI: 10.1016/j.gendis.2019.12.013

Abstract

Thousands of long non-coding RNAs (lncRNAs) have been discovered in human genomes by gene chip, next-generation sequencing, and/or other methods in recent years, which represent a significant subset of the universal genes involved in a wide range of biological functions. An abnormal expression of lncRNAs is associated with the growth, invasion, and metastasis of various types of human cancers, including hepatocellular carcinoma (HCC), which is an aggressive, highly malignant, and invasive tumor, and a poor prognosis in China. With a more in-depth understanding of lncRNA research for HCC and the emergence of new molecular-targeted therapies, the diagnosis, treatment, and prognosis of HCC will be considerably improved. Therefore, this review is expected to provide recommendations and directions for future lncRNA research for HCC.

Keywords

AASLD, American Association for the Study of Liver Diseases HCC HCC, Hepatocellular carcinoma RNA, Ribonucleic acid ceRNAs ceRNAs, Competing endogenous RNAs lncRNAs lncRNAs, Long non-coding RNAs mRNA, Messenger RNA miRNAs miRNAs, microRNAs ncRNAs ncRNAs, Non-coding RNAs snoRNAs snoRNAs, Small nucleolar RNAs

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