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Psychopharmacology
Sep, 2021;238 (9): 2449-2457.

Effect of Bifidobacterium on olanzapine-induced body weight and appetite changes in patients with psychosis.

Ye Yang, Yujun Long, Dongyu Kang, Chenchen Liu, Jingmei Xiao, Renrong Wu, Jingping Zhao
Author Information
  1. Ye Yang: National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, 410011, Hunan, China.
  2. Yujun Long: National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, 410011, Hunan, China.
  3. Dongyu Kang: National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, 410011, Hunan, China.
  4. Chenchen Liu: National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, 410011, Hunan, China.
  5. Jingmei Xiao: National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, 410011, Hunan, China.
  6. Renrong Wu: National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, 410011, Hunan, China. wurenrong@csu.edu.cn.
  7. Jingping Zhao: National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, 410011, Hunan, China.
PMID: 34002246 DOI: 10.1007/s00213-021-05866-z

Abstract

RATIONALE: Gut microbiota plays an important role in host metabolism. Antipsychotic drugs can result in metabolic abnormalities. Probiotics may ameliorate the antipsychotic drug-induced metabolic abnormalities by regulating gut microbiota.
OBJECTIVE: To determine whether Bifidobacterium intervention can ameliorate olanzapine-induced weight increase.
METHODS: Enrolled patients were assigned to either the olanzapine or olanzapine plus Bifidobacterium group. The following were assessed: body weight, body mass index (BMI), appetite, latency to increased appetite, and baseline weight increase of more than 7%. All assessments were conducted at baseline and at 4, 8, and 12 weeks of treatment.
RESULTS: We enrolled 70 patients with schizophrenia or schizophrenic affective disorder, and 67 completed the study. Treatment for 4 weeks led to between-group differences in weight change (2.4 vs. 1.1 kg, p < 0.05) and BMI (0.9 vs. 0.4, p < 0.05). However, this difference disappeared at 8 and 12 weeks of treatment (both p > 0.05). The two groups did not differ in appetite increase at any time point (p > 0.05). The mean time from olanzapine initiation to appetite increase was also not significantly different between the two groups (t = 1.243, p = 0.220).
CONCLUSIONS: Probiotics may mitigate olanzapine-induced weight gain in the early stage of treatment and delay olanzapine-induced appetite increase.

Keywords

Appetite Bifidobacterium Olanzapine Schizophrenia Weight gain

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Grants

  1. 2016YFC1306900/the National Key Research and Development Program of China
  2. 81622018/the National Natural Science Foundation of China

MeSH Term

Antipsychotic Agents
Appetite
Benzodiazepines
Bifidobacterium
Body Mass Index
Body Weight
Humans
Olanzapine
Psychotic Disorders

Chemicals

Antipsychotic Agents
Benzodiazepines
Olanzapine
Journal Article
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0weightappetiteincreaseBifidobacteriumolanzapine-induced05patientsolanzapinebody4treatmentmicrobiotacanmetabolicabnormalitiesProbioticsmayameliorateBMIbaseline812 weeksvsp < 00p > 0twogroupstimegainRATIONALE:GutplaysimportantrolehostmetabolismAntipsychoticdrugsresultantipsychoticdrug-inducedregulatinggutOBJECTIVE:determinewhetherinterventionMETHODS:Enrolledassignedeitherplusgroupfollowingassessed:massindexlatencyincreased7%assessmentsconductedRESULTS:enrolled70schizophreniaschizophrenicaffectivedisorder67completedstudyTreatment4 weeksledbetween-groupdifferenceschange211 kg9Howeverdifferencedisappeareddifferpointmeaninitiationalsosignificantlydifferentt = 1243p = 0220CONCLUSIONS:mitigateearlystagedelayEffectchangespsychosisAppetiteOlanzapineSchizophreniaWeight

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