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Antibiotics (Basel, Switzerland)
May 02, 2021;10 (5):

Insights into Emergence of Antibiotic Resistance in Acid-Adapted Enterohaemorrhagic .

Salma Waheed Sheikh, Ahmad Ali, Asma Ahsan, Sidra Shakoor, Fei Shang, Ting Xue
Author Information
  1. Salma Waheed Sheikh: School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
  2. Ahmad Ali: School of Agronomy, Anhui Agricultural University, Hefei 230036, China.
  3. Asma Ahsan: Faculty of Life Sciences, University of Central Punjab, Lahore 54000, Punjab, Pakistan.
  4. Sidra Shakoor: Station de Neucfchateau, CIRAD, 97130 Sainte-Marie, Capesterre Belle Eau, Guadeloupe, France.
  5. Fei Shang: School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
  6. Ting Xue: School of Life Sciences, Anhui Agricultural University, Hefei 230036, China. ORCID
PMID: 34063307 DOI: 10.3390/antibiotics10050522

Abstract

The emergence of multidrug-resistant pathogens presents a global challenge for treating and preventing disease spread through zoonotic transmission. The water and foodborne Enterohaemorrhagic (EHEC) are capable of causing intestinal and systemic diseases. The root cause of the emergence of these strains is their metabolic adaptation to environmental stressors, especially acidic pH. Acid treatment is desired to kill pathogens, but the protective mechanisms employed by EHECs cross-protect against antimicrobial peptides and thus facilitate opportunities for survival and pathogenesis. In this review, we have discussed the correlation between acid tolerance and antibiotic resistance, highlighting the identification of novel targets for potential production of antimicrobial therapeutics. We have also summarized the molecular mechanisms used by acid-adapted EHECs, such as the two-component response systems mediating structural modifications, competitive inhibition, and efflux activation that facilitate cross-protection against antimicrobial compounds. Moving beyond the descriptive studies, this review highlights low pH stress as an emerging player in the development of cross-protection against antimicrobial agents. We have also described potential gene targets for innovative therapeutic approaches to overcome the risk of multidrug-resistant diseases in healthcare and industry.

Keywords

acid tolerance cross-protection enterohaemorrhagic Escherichia coli foodborne infections multidrug resistance two-component signaling system

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Grants

  1. 31672571/National Natural Science Foundation of China
Journal Article Review
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Word Cloud

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