Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD).
Fang Lv, Xueying Wu, Jin Song, Pan Wang, Shucheng Ren, Wei Guo, Qi Xue, Henghui Zhang, Jun Zhao
Author Information
Fang Lv: Department of Thoracic Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China.
Xueying Wu: Beijing Shijitan Hospital, Ninth School of Clinical Medicine, School of Oncology, Capital Medical University, Peking University, Capital Medical University, 100038, Beijing, China.
Jin Song: Immupeutics Medicine Institute, Beijing, China.
Pan Wang: Department of Thoracic Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China.
Shucheng Ren: Immupeutics Medicine Institute, Beijing, China.
Wei Guo: Department of Thoracic Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China.
Qi Xue: Department of Thoracic Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China. xueqi@cicams.ac.cn.
Henghui Zhang: Beijing Shijitan Hospital, Ninth School of Clinical Medicine, School of Oncology, Capital Medical University, Peking University, Capital Medical University, 100038, Beijing, China. zhhbao@ccmu.edu.cn. ORCID
Jun Zhao: Department of Thoracic Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China. drzhaojun@126.com.
It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.
