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Circulation research
06 11, 2021;128 (12): 1927-1943.

Bench-to-Bedside in Vascular Medicine: Optimizing the Translational Pipeline for Patients With Peripheral Artery Disease.

Tom Alsaigh, Belinda A Di Bartolo, Jocelyne Mulangala, Gemma A Figtree, Nicholas J Leeper
Author Information
  1. Tom Alsaigh: Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA (T.A., N.J.L.).
  2. Belinda A Di Bartolo: Cardiothoracic and Vascular Health, Kolling Institute and Department of Cardiology, Royal North Shore Hospital, Northern Sydney Local Health District, Australia (B.A.D.B., G.A.F.).
  3. Jocelyne Mulangala: Centenary Institute, Sydney, Australia (J.M.).
  4. Gemma A Figtree: Cardiothoracic and Vascular Health, Kolling Institute and Department of Cardiology, Royal North Shore Hospital, Northern Sydney Local Health District, Australia (B.A.D.B., G.A.F.).
  5. Nicholas J Leeper: Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA (T.A., N.J.L.).
PMID: 34110900 DOI: 10.1161/CIRCRESAHA.121.318265

Abstract

Peripheral arterial disease is a growing worldwide problem with a wide spectrum of clinical severity and is projected to consume >$21 billion per year in the United States alone. While vascular researchers have brought several therapies to the clinic in recent years, few of these approaches have leveraged advances in high-throughput discovery screens, novel translational models, or innovative trial designs. In the following review, we discuss recent advances in unbiased genomics and broader omics technology platforms, along with preclinical vascular models designed to enhance our understanding of disease pathobiology and prioritize targets for additional investigation. Furthermore, we summarize novel approaches to clinical studies in subjects with claudication and ischemic ulceration, with an emphasis on streamlining and accelerating bench-to-bedside translation. By providing a framework designed to enhance each aspect of future clinical development programs, we hope to enrich the pipeline of therapies that may prevent loss of life and limb for those with peripheral arterial disease.

Keywords

atherosclerosis cardiology endothelial cell genomics peripheral arterial disease

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Grants

  1. R35 HL144475/NHLBI NIH HHS
  2. T32 HL098049/NHLBI NIH HHS

MeSH Term

Animals
Atherosclerosis
Endothelial Cells
Genome-Wide Association Study
Genomics
High-Throughput Nucleotide Sequencing
Humans
In Vitro Techniques
Intermittent Claudication
Ischemia
Leg Ulcer
Mice
Models, Animal
Nanoparticles
Neovascularization, Physiologic
Peripheral Arterial Disease
Pluripotent Stem Cells
Single-Cell Analysis
Translational Research, Biomedical
Wound Healing
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 16

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