Seq-ing out cell types across the isocortex and hippocampal formation.

Guo-Li Ming, Hongjun Song
Author Information
  1. Guo-Li Ming: Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: gming@pennmedicine.upenn.edu.
  2. Hongjun Song: Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

A central quest in neuroscience is to gain a holistic understanding of all cell types in the brain. In this issue of Cell, Yao et al. establish a molecular architectural view of cell types across the entire adult mouse isocortex and hippocampal formation and reveal surprising similarities of cell types in these two brain regions.

References

  1. Nat Rev Neurosci. 2009 Oct;10(10):724-35 [PMID: 19763105]
  2. Cell. 2015 May 21;161(5):1202-1214 [PMID: 26000488]
  3. Nature. 2007 Jan 11;445(7124):168-76 [PMID: 17151600]
  4. Neurobiol Dis. 2020 Dec;146:105139 [PMID: 33065280]
  5. Neuron. 2017 Nov 1;96(3):542-557 [PMID: 29096072]
  6. Cell. 2021 Jun 10;184(12):3222-3241.e26 [PMID: 34004146]
  7. Neuron. 2011 May 26;70(4):687-702 [PMID: 21609825]
  8. Nat Neurosci. 2016 Feb;19(2):335-46 [PMID: 26727548]

Grants

  1. R35 NS097370/NINDS NIH HHS
  2. RF1 MH123979/NIMH NIH HHS

MeSH Term

Animals
Hippocampus
Mice
Neocortex

Word Cloud

Created with Highcharts 10.0.0celltypesbrainacrosshippocampalformationcentralquestneurosciencegainholisticunderstandingissueof CellYaoet alestablishmoleculararchitecturalviewentireadultmouseisocortex andrevealsurprisingsimilaritiestworegionsSeq-ingisocortex

Similar Articles

Cited By

No available data.