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May, 2021;30 (5): 631-642.

Promoting effect of the Maillard reaction products produced during the stir-frying process of on the intestinal absorption of active ingredients in .

Lu Wu, Li Xia Tan, Fen Fang Gong, Yu Xia, Rui Ge Chu, Hua Sheng Yang
Author Information
  1. Lu Wu: School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
  2. Li Xia Tan: School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
  3. Fen Fang Gong: School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
  4. Yu Xia: School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
  5. Rui Ge Chu: Jiangxi Hospital of Traditional Chinese Medicine, Affiliated to Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
  6. Hua Sheng Yang: School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China. ORCID
PMID: 34123460 DOI: 10.1007/s10068-021-00911-1

Abstract

This study was designed to evaluate the absorption promoting capacity of Maillard Reaction Products (MRPs) produced during the stir-frying process of on catechin, ferulic acid, quercetin and kaempferol by the ex vivo rat everted gut sac model, in situ single-pass intestinal perfusion model and the whole animal model. Moreover, verapamil, EDTA and mannitol were used for determining the transport mechanism of catechin, ferulic acid, quercetin and kaempferol. The tight junction (TJ) proteins including zonula occudens-1(ZO-1) and claudin-1 were chosen to investigate the promoting mechanism of MRPs by quantitative real-time PCR (qRT-PCR) and western blot analyses. The results showed that the MRPs produced during the stir-frying process of could improve the intestinal absorption of catechin, ferulic acid, quercetin and kaempferol. And the absorption-promoting effect of MRPs was related to chelating effect and the reduced expression of claudin-1 and ZO-1. Our results suggested that MRPs could be promising oral absorption promoters, which might be another processing mechanism of .

Keywords

Absorption promoter Hordei Fructus Germinatus Intestinal absorption Maillard reaction product Transport mechanism

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Journal Article

Word Cloud

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