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Antimicrobial agents and chemotherapy
08 17, 2021;65 (9): e0070921.

Efficacy of Omadacycline against Multidrug-Resistant Enterococcus faecium Strains in a Mouse Peritonitis Model.

Kavindra V Singh, Cesar A Arias, Barbara E Murray
Author Information
  1. Kavindra V Singh: Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  2. Cesar A Arias: Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  3. Barbara E Murray: Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
PMID: 34125596 DOI: 10.1128/AAC.00709-21

Abstract

Omadacycline (OMC) showed better potency than daptomycin (DAP) or vancomycin (VAN) against Van, Amp, DAP-nonsusceptible, linezolid-resistant, (B) Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable and efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.

Keywords

E. faecium mouse peritonitis omadacycline

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Grants

  1. R21 AI133289/NIAID NIH HHS
  2. R00 AI072961/NIAID NIH HHS
  3. R01 AI093749/NIAID NIH HHS
  4. R01 AI148342/NIAID NIH HHS
  5. P01 AI152999/NIAID NIH HHS
  6. R21AI133289-01A1/HHS | National Institutes of Health (NIH)
  7. T32 AI141349/NIAID NIH HHS
  8. R21 AI143229/NIAID NIH HHS
  9. R01 AI134637/NIAID NIH HHS
  10. UM1 AI104681/NIAID NIH HHS
  11. R01 AI121400/NIAID NIH HHS
  12. K24 AI121296/NIAID NIH HHS

MeSH Term

Animals
Anti-Bacterial Agents
Enterococcus faecium
Gram-Positive Bacterial Infections
Mice
Microbial Sensitivity Tests
Peritonitis
Tetracyclines

Chemicals

Anti-Bacterial Agents
Tetracyclines
omadacycline
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

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