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06 30, 2021;12 (7):

Genome Reorganization during Erythroid Differentiation.

Anastasia Ryzhkova, Nariman Battulin
Author Information
  1. Anastasia Ryzhkova: Institute of Cytology and Genetics SB RAS, Laboratory of Developmental Genetics, 630090 Novosibirsk, Russia.
  2. Nariman Battulin: Institute of Cytology and Genetics SB RAS, Laboratory of Developmental Genetics, 630090 Novosibirsk, Russia.
PMID: 34208866 DOI: 10.3390/genes12071012

Abstract

Hematopoiesis is a convenient model to study how chromatin dynamics plays a decisive role in regulation of cell fate. During erythropoiesis a population of stem and progenitor cells becomes increasingly lineage restricted, giving rise to terminally differentiated progeny. The concerted action of transcription factors and epigenetic modifiers leads to a silencing of the multipotent transcriptome and activation of the transcriptional program that controls terminal differentiation. This article reviews some aspects of the biology of red blood cells production with the focus on the extensive chromatin reorganization during differentiation.

Keywords

3D genomics TADs chromatin organization erythroid differentiation

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MeSH Term

Animals
Cell Differentiation
Cell Lineage
Chromatin Assembly and Disassembly
Erythroid Precursor Cells
Erythropoiesis
Gene Expression Regulation
Genome
Humans
Transcription Factors

Chemicals

Transcription Factors
Journal Article Review
Article has an altmetric score of 1

Word Cloud

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