Fe(III)-mediated reversible catalytic activity of MoS nanozymes for bisphosphonate drug sensing.
Pu Zhang, Wanqiang Xia, Ping Deng, Yuanhong Min, Juan Tan, Yi Wang, Wensheng Fu
Author Information
Pu Zhang: Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
Wanqiang Xia: Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, PR China.
Ping Deng: Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
Yuanhong Min: Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, PR China.
Juan Tan: Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, PR China.
Yi Wang: Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, PR China. Electronic address: ywang@cqnu.edu.cn.
Wensheng Fu: Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, PR China. Electronic address: fuwensheng@cqnu.edu.cn.
Peroxidase-like activity of MoS quantum dots (QDs) can be reversibly regulated by means of Fe/alendronate sodium (ALDS)-induced aggregation/disaggregation of the QDs in solution. Specifically, Fe can selectively aggregate the MoS QDs and thus greatly enhance their peroxidase-like activity, while such enhancement can be inhibited in the presence of ALDS owing to the competitive coordination of ALDS with Fe. By regulating the enzyme-like activity of MoS QDs, different colorimetric signal of a typical substrate of horseradish peroxidase, 3,3΄,5,5΄-tetramethylbenzidine, can be measured in the presence of HO. Based on this mechanism, we develop a colorimetric approach for the determination of ALDS and further applied in quality control of pharmaceutical products, utilizing either smartphone or UV-vis spectrometer as a readout. This detection method is rapid and selective, where derivatization of ALDS before detection is not needed. Such a smartphone-based colorimetric detection platform is promising to be applied in point-of-care testing at home, small clinics, or underdeveloped regions.
