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Neurocritical care
07, 2021;35 (Suppl 1): 4-23.

Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.

Jan Claassen, Yama Akbari, Sheila Alexander, Mary Kay Bader, Kathleen Bell, Thomas P Bleck, Melanie Boly, Jeremy Brown, Sherry H-Y Chou, Michael N Diringer, Brian L Edlow, Brandon Foreman, Joseph T Giacino, Olivia Gosseries, Theresa Green, David M Greer, Daniel F Hanley, Jed A Hartings, Raimund Helbok, J Claude Hemphill, H E Hinson, Karen Hirsch, Theresa Human, Michael L James, Nerissa Ko, Daniel Kondziella, Sarah Livesay, Lori K Madden, Shraddha Mainali, Stephan A Mayer, Victoria McCredie, Molly M McNett, Geert Meyfroidt, Martin M Monti, Susanne Muehlschlegel, Santosh Murthy, Paul Nyquist, DaiWai M Olson, J Javier Provencio, Eric Rosenthal, Gisele Sampaio Silva, Simone Sarasso, Nicholas D Schiff, Tarek Sharshar, Lori Shutter, Robert D Stevens, Paul Vespa, Walter Videtta, Amy Wagner, Wendy Ziai, John Whyte, Elizabeth Zink, Jose I Suarez, Curing Coma Campaign
Author Information
  1. Jan Claassen: Department of Neurology, Columbia University and New York-Presbyterian Hospital, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York City, NY, 10032, USA. jc1439@columbia.edu. ORCID
  2. Yama Akbari: Departments of Neurology, Neurological Surgery, and Anatomy & Neurobiology and Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, USA.
  3. Sheila Alexander: Acute and Tertiary Care, School of Nursing and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  4. Mary Kay Bader: Mission Hospital, Mission Viejo, CA, USA.
  5. Kathleen Bell: Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  6. Thomas P Bleck: Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  7. Melanie Boly: Department of Neurology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
  8. Jeremy Brown: Office of Emergency Care Research, Division of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
  9. Sherry H-Y Chou: Departments of Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  10. Michael N Diringer: Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
  11. Brian L Edlow: Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital and Harvard Medical School, Harvard University, Boston, MA, USA.
  12. Brandon Foreman: Departments of Neurology and Rehabilitation Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
  13. Joseph T Giacino: Department of Physical Medicine and Rehabilitation, Harvard Medical School, Harvard University, Boston, MA, USA.
  14. Olivia Gosseries: GIGA Consciousness After Coma Science Group, University of Liege, Liege, Belgium.
  15. Theresa Green: School of Nursing, Queensland University of Technology, Kelvin Grove, QLD, Australia.
  16. David M Greer: Department of Neurology, School of Medicine, Boston University, Boston, MA, USA.
  17. Daniel F Hanley: Division of Brain Injury Outcomes, Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  18. Jed A Hartings: Department of Neurosurgery, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
  19. Raimund Helbok: Neurocritical Care Unit, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  20. J Claude Hemphill: Department of Neurology, Weill Institute for Neurosciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  21. H E Hinson: Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
  22. Karen Hirsch: Department of Neurology, Stanford University, Palo Alto, CA, USA.
  23. Theresa Human: Department of Pharmacy, Barnes Jewish Hospital, St. Louis, MO, USA.
  24. Michael L James: Departments of Anesthesiology and Neurology, Duke University, Durham, NC, USA.
  25. Nerissa Ko: Department of Neurology, Weill Institute for Neurosciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  26. Daniel Kondziella: Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  27. Sarah Livesay: College of Nursing, Rush University, Chicago, IL, USA.
  28. Lori K Madden: Center for Nursing Science, University of California, Davis, Sacramento, CA, USA.
  29. Shraddha Mainali: Department of Neurology, The Ohio State University, Columbus, OH, USA.
  30. Stephan A Mayer: Department of Neurology, New York Medical College, Valhalla, NY, USA.
  31. Victoria McCredie: Interdepartmental Division of Critical Care, Department of Respirology, University of Toronto, Toronto, ON, Canada.
  32. Molly M McNett: College of Nursing, The Ohio State University, Columbus, OH, USA.
  33. Geert Meyfroidt: Department of Intensive Care Medicine, University Hospitals Leuven and University of Leuven, Leuven, Belgium.
  34. Martin M Monti: Departments of Neurosurgery and Psychology, Brain Injury Research Center, University of California, Los Angeles, Los Angeles, CA, USA.
  35. Susanne Muehlschlegel: Departments of Neurology, Anesthesiology/Critical Care, and Surgery, Medical School, University of Massachusetts, Worcester, MA, USA.
  36. Santosh Murthy: Department of Neurology, Weill Cornell Medical College, New York City, NY, USA.
  37. Paul Nyquist: Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  38. DaiWai M Olson: Departments of Neurology and Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  39. J Javier Provencio: Departments of Neurology and Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA.
  40. Eric Rosenthal: Department of Neurology, Harvard Medical School, Harvard University, Boston, MA, USA.
  41. Gisele Sampaio Silva: Department of Neurology, Albert Einstein Israelite Hospital and Universidade Federal de São Paulo, São Paulo, Brazil.
  42. Simone Sarasso: Department of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy.
  43. Nicholas D Schiff: Department of Neurology and Brain Mind Research Institute, Weill Cornell Medicine, Cornell University, New York City, NY, USA.
  44. Tarek Sharshar: Department of Intensive Care, Paris Descartes University, Paris, France.
  45. Lori Shutter: Departments of Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  46. Robert D Stevens: Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  47. Paul Vespa: Departments of Neurosurgery and Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
  48. Walter Videtta: National Hospital Alejandro Posadas, Buenos Aires, Argentina.
  49. Amy Wagner: Department of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  50. Wendy Ziai: Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  51. John Whyte: Moss Rehabilitation Research Institute, Elkins Park, PA, USA.
  52. Elizabeth Zink: Division of Neurosciences Critical Care, Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  53. Jose I Suarez: Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
PMID: 34236619 DOI: 10.1007/s12028-021-01260-x

Abstract

Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.

Keywords

Biomarkers Coma Consciousness Electrophysiology Magnetic resonance imaging

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Grants

  1. R21 NS113037/NINDS NIH HHS
  2. UL1 TR001863/NCATS NIH HHS
  3. R03 NS112760/NINDS NIH HHS
  4. R01 NS106014/NINDS NIH HHS

MeSH Term

Biomarkers
Coma
Congresses as Topic
Consciousness
Consciousness Disorders
Humans
National Institutes of Health (U.S.)
United States

Chemicals

Biomarkers
Journal Article Research Support, N.I.H., Extramural
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