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Environmental science and pollution research international
Dec, 2021;28 (47): 67053-67065.

The relationship between maternal perfluoroalkylated substances exposure and low birth weight of offspring: a systematic review and meta-analysis.

Tengrui Cao, Aibin Qu, Zixuan Li, Wenjuan Wang, Ran Liu, Xue Wang, Yaxiong Nie, Suju Sun, Xiaolin Zhang, Xuehui Liu
Author Information
  1. Tengrui Cao: Department of Preventive Medicine, School of Public Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China.
  2. Aibin Qu: Department of Preventive Medicine, School of Public Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China.
  3. Zixuan Li: Department of Epidemiology and Hygienic Statistics, School of Public Health, Hebei Province Key Laboratory of Environment and Human Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China.
  4. Wenjuan Wang: Department of Epidemiology and Hygienic Statistics, School of Public Health, Hebei Province Key Laboratory of Environment and Human Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China.
  5. Ran Liu: Department of Epidemiology and Hygienic Statistics, School of Public Health, Hebei Province Key Laboratory of Environment and Human Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China.
  6. Xue Wang: Department of Epidemiology and Hygienic Statistics, School of Public Health, Hebei Province Key Laboratory of Environment and Human Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China.
  7. Yaxiong Nie: Department of Epidemiology and Hygienic Statistics, School of Public Health, Hebei Province Key Laboratory of Environment and Human Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China.
  8. Suju Sun: Department of Occupational and Environmental Health, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China.
  9. Xiaolin Zhang: Department of Epidemiology and Hygienic Statistics, School of Public Health, Hebei Province Key Laboratory of Environment and Human Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China. Luckyzhang77@163.com.
  10. Xuehui Liu: Department of Occupational and Environmental Health, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, People's Republic of China. lxh19762006@163.com. ORCID
PMID: 34244932 DOI: 10.1007/s11356-021-15061-4

Abstract

Some studies have shown that maternal perfluoroalkylated substances (PFAS) exposure may be associated with low birth weight (LBW) of offspring. We conducted a meta-analysis to assess the association between maternal PFASs exposure and LBW in offspring. The researchers searched PubMed, Science Direct, Scopus, Google Scholar, Web of Science, and Embase to find all the articles before October 2020. The Newcastle-Ottawa Scale was used to evaluate the quality of the studies. Finally, six articles were included for meta-analysis. Our meta-analysis showed no significant correlation between maternal perfluorooctanoic acid (PFOA) exposure and LBW of offspring: odds ratio (OR) = 0.90, 95% confidence interval (95% CI) = 0.80-1.01, with low heterogeneity (I = 18.4%, P = 0.289); there was a significant positive correlation between maternal perfluorooctane sulfonate (PFOS) exposure and LBW of offspring (OR = 1.32, 95% CI = 1.09-1.55) with no heterogeneity (I = 0.00%, P = 0.570). The grouping analysis of PFOS showed was a significant positive correlation between maternal PFOS exposure and LBW of offspring in American (OR = 1.44, 95% CI = 1.15-1.72). This study provided a systematic review and meta-analysis evidence for the relationship between maternal PFASs exposure and LBW of offspring through a small number of studies. Researchers should conduct further studies between different regions.

Keywords

Meta-analysis low birth weight maternal exposure offspring perfluoroalkylated substances systematic review

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Grants

  1. USIP2019032/Innovative experiment project of Hebei Medical University

MeSH Term

Female
Humans
Infant, Low Birth Weight
Infant, Newborn
Maternal Exposure
Odds Ratio
Journal Article Meta-Analysis Systematic Review
Article has an altmetric score of 1

Word Cloud

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