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Journal of hematology & oncology
07 27, 2021;14 (1): 117.

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential.

Wei Huang, Tian-Qi Chen, Ke Fang, Zhan-Cheng Zeng, Hua Ye, Yue-Qin Chen
Author Information
  1. Wei Huang: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.
  2. Tian-Qi Chen: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.
  3. Ke Fang: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.
  4. Zhan-Cheng Zeng: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.
  5. Hua Ye: Department of Hepatobiliary, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China.
  6. Yue-Qin Chen: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China. lsscyq@mail.sysu.edu.cn. ORCID
PMID: 34315512 DOI: 10.1186/s13045-021-01129-8

Abstract

N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscriptional regulation. To date, m6A methyltransferases have been reported to execute m6A deposition on distinct RNAs by their own or forming different complexes with additional partner proteins. In this review, we summarize the function of these m6A methyltransferases or complexes in regulating the key genes and pathways of cancer biology. We also highlight the progress in the use of m6A methyltransferases in mediating therapy resistance, including chemotherapy, targeted therapy, immunotherapy and radiotherapy. Finally, we discuss the current approaches and clinical potential of m6A methyltransferase-targeting strategies.

Keywords

Cancer Drug discovery Therapy resistance m6A m6A methyltransferase

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MeSH Term

Adenosine
Animals
Gene Expression Regulation, Neoplastic
Humans
Methyltransferases
Molecular Targeted Therapy
Neoplasms
Signal Transduction

Chemicals

N-methyladenosine
6-methyladenine mRNA methyltransferase
Methyltransferases
Adenosine
Journal Article Research Support, Non-U.S. Gov't Review
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Word Cloud

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