Shih-Chiang Lo: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Chao-Xuan You: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Bo-Ren Chen: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Ching-Chu Hsieh: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Cheng-En Li: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Che-Chi Shu: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan. cshu@ntut.edu.tw.
There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits inspired by the fim operon in Escherichia coli, we found that cells exchanged the distribution of the upstream transcription factor (TF) for the transitional frequency of DNA. Then cells do an inverse transform, which exchanges the transitional frequency of DNA for the distribution of downstream products. Due to this special feature, DNA in the system of frequency modulation is able to reset the noise. By probability generating function, we know the ranges of parameter values that grant such an interesting phenomenon.
References
ACS Synth Biol. 2015 Feb 20;4(2):116-25
[PMID: 24735052]
Cell Syst. 2018 Oct 24;7(4):384-397.e6
[PMID: 30243562]
