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Psychiatric genetics
10 01, 2021;31 (5): 145-161.

Epigenetic marks in suicide: a review.

Daniel F Ramos-Rosales, Fernando Vazquez-Alaniz, Norma Urtiz-Estrada, Eda G Ramirez-Valles, Edna M Mendez-Hernádez, Alma C Salas-Leal, Marcelo Barraza-Salas
Author Information
  1. Daniel F Ramos-Rosales: Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango.
  2. Fernando Vazquez-Alaniz: Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango.
  3. Norma Urtiz-Estrada: Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango.
  4. Eda G Ramirez-Valles: Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango.
  5. Edna M Mendez-Hernádez: Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, México.
  6. Alma C Salas-Leal: Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, México.
  7. Marcelo Barraza-Salas: Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango.
PMID: 34412082 DOI: 10.1097/YPG.0000000000000297

Abstract

Suicide is a complex phenomenon and a global public health problem that involves several biological factors that could contribute to the pathophysiology of suicide. There is evidence that epigenetic factors influence some psychiatric disorders, suggesting a predisposition to suicide or suicidal behavior. Here, we review studies of molecular mechanisms of suicide in an epigenetic perspective in the postmortem brain of suicide completers and peripheral blood cells of suicide attempters. Besides, we include studies of gene-specific DNA methylation, epigenome-wide association, histone modification, and interfering RNAs as epigenetic factors. This review provides an overview of the epigenetic mechanisms described in different biological systems related to suicide, contributing to an understanding of the genetic regulation in suicide. We conclude that epigenetic marks are potential biomarkers in suicide, and they could become attractive therapeutic targets due to their reversibility and importance in regulating gene expression.

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MeSH Term

Biomarkers
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation
Genetic Predisposition to Disease
Genome-Wide Association Study
Histone Code
Humans
Mental Disorders
RNA, Small Interfering
Self-Injurious Behavior
Suicide

Chemicals

Biomarkers
RNA, Small Interfering
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 2

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