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Biochemical Society transactions
08 27, 2021;49 (4): 1633-1641.

Lipid-protein interactions in virus assembly and budding from the host cell plasma membrane.

Balindile B Motsa, Robert V Stahelin
Author Information
  1. Balindile B Motsa: Department of Medicinal Chemistry & Molecular Pharmacology and the Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47906, U.S.A.
  2. Robert V Stahelin: Department of Medicinal Chemistry & Molecular Pharmacology and the Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47906, U.S.A. ORCID
PMID: 34431495 DOI: 10.1042/BST20200854

Abstract

Lipid enveloped viruses contain a lipid bilayer coat that protects their genome to help facilitate entry into the new host cell. This lipid bilayer comes from the host cell which they infect. After viral replication, the mature virion hijacks the host cell plasma membrane where it is then released to infect new cells. This process is facilitated by the interaction between phospholipids that make up the plasma membrane and specialized viral matrix proteins. This step in the viral lifecycle may represent a viable therapeutic strategy for small molecules that aim to block enveloped virus spread. In this review, we summarize the current knowledge on the role of plasma membrane lipid-protein interactions on viral assembly and budding.

Keywords

Ebola virus HIV Marburg virus lipid–protein interaction virus assembly virus budding

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Grants

  1. R01 AI081077/NIAID NIH HHS
  2. R21 AI139950/NIAID NIH HHS
  3. R21 AI142651/NIAID NIH HHS

MeSH Term

Cell Membrane
Host-Pathogen Interactions
Lipids
Proteins
Virus Assembly

Chemicals

Lipids
Proteins
Journal Article Research Support, N.I.H., Extramural Review
Article has an altmetric score of 3

Word Cloud

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