Nanoemulsions as novel nanocarrieres for drug delivery across the skin: In-vitro, in-vivo evaluation of miconazole nanoemulsions for treatment of .
Umar Farooq, Akhtar Rasul, Muhammad Zafarullah, Ghulam Abbas, Maria Rasool, Farman Ali, Shabbir Ahmed, Zeeshan Javaid, Zoya Abid, Humayun Riaz, Rana Khalid Mahmood Arshad, Shayan Maryam, Naseem Amna, Kanwal Asif
Author Information
Umar Farooq: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Punjab, Pakistan.
Akhtar Rasul: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Punjab, Pakistan. ORCID
Muhammad Zafarullah: Emergency Department, Punjab Institute of Cardiology, Lahore, Pakistan.
Ghulam Abbas: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Punjab, Pakistan.
Maria Rasool: Government College University Faisalabad, Pakistan.
Farman Ali: Beaumont Hospital Dearborn, Michigan, USA.
Shabbir Ahmed: Department of Chemical Engineering, Centre for Synthetic Biology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China.
Zeeshan Javaid: Department of Pharmacy, Mirpur University of Science and Technology, Mirpur, Azad Kashmir, Pakistan.
Zoya Abid: Department of Pharmacy, Islam College of Pharmacy, Sialkot, Pakistan.
Humayun Riaz: Department of Pharmacy, Rashid Latif College of Pharmacy, Lahore, Pakistan.
Rana Khalid Mahmood Arshad: Department of Pharmacy, Rashid Latif College of Pharmacy, Lahore, Pakistan.
Shayan Maryam: Department of Pharmacy, Rashid Latif College of Pharmacy, Lahore, Pakistan.
Naseem Amna: Department of Pharmacy, Rashid Latif College of Pharmacy, Lahore, Pakistan.
Kanwal Asif: Department of Pharmacy, Rashid Latif College of Pharmacy, Lahore, Pakistan.
In the current research, attempt is made to fabricate a nanoemulsion (NE) containing an antifungal agent. The prepared formulation has been expected to enhance skin penetration. It is also studied for in vitro drug release and toxicity assessment. Spontaneous titration method was used for preparation of NE. Prepared NE were characterized for their charge, size, morphology, rheological behaviour, drug release profile, skin permeability. The drug permeation and skin irritation were investigated. The in vitro antifungal activity was inspected using the well agar diffusion method. Miconazole NE showed good penetration in the skin as compared to marketed products. SEM showed semispherical shapes of the droplets. Zeta potential and zeta sizer showed that size was in nano ranges having positive charge.
