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08 20, 2021;13 (8):

Inhibition of Diarrheal Shellfish Toxins Accumulation in the Mussel by Curcumin and Underlying Mechanisms.

Kuan-Kuan Yuan, Guo-Fang Duan, Qing-Yuan Liu, Hong-Ye Li, Wei-Dong Yang
Author Information
  1. Kuan-Kuan Yuan: Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. ORCID
  2. Guo-Fang Duan: Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  3. Qing-Yuan Liu: Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  4. Hong-Ye Li: Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. ORCID
  5. Wei-Dong Yang: Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
PMID: 34437449 DOI: 10.3390/toxins13080578

Abstract

Diarrheal shellfish toxins (DSTs) are among the most widely distributed phytotoxins, and are associated with diarrheal shellfish poisoning (DSP) events in human beings all over the world. Therefore, it is urgent and necessary to identify an effective method for toxin removal in bivalves. In this paper, we found that curcumin (CUR), a phytopolylphenol pigment, can inhibit the accumulation of DSTs (okadaic acid-eq) in the digestive gland of after exposure. qPCR results demonstrated that CUR inhibited the induction of DSTs on the aryl hydrocarbon receptor (AhR), hormone receptor 96 (HR96) and CYP3A4 mRNA, indicating that the CUR-induced reduction in DSTs may be correlated with the inhibition of transcriptional induction of AhR, HR96 and CYP3A4. The histological examination showed that cells caused severe damage to the digestive gland of , and the addition of curcumin effectively alleviated the damage induced by . In conclusion, our findings provide a potential method for the effective removal of toxins from DST-contaminated shellfish.

Keywords

AhR CUR CYP3A4 DSTs HR96 Perna viridis

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MeSH Term

Animals
Curcumin
Diarrhea
Humans
Inactivation, Metabolic
Marine Toxins
Okadaic Acid
Perna
Shellfish Poisoning

Chemicals

Marine Toxins
Okadaic Acid
Curcumin
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

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