Potential of Activin B as a Clinical Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

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Sabine Gravelsina, Zaiga Nora-Krukle, Anda Vilmane, Simons Svirskis, Katrine Vecvagare, Angelika Krumina, Modra Murovska

Author Information

Sabine Gravelsina: Institute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites Str., LV-1067 Riga, Latvia.
Zaiga Nora-Krukle: Institute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites Str., LV-1067 Riga, Latvia. ORCID
Anda Vilmane: Institute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites Str., LV-1067 Riga, Latvia. ORCID
Simons Svirskis: Institute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites Str., LV-1067 Riga, Latvia. ORCID
Katrine Vecvagare: Institute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites Str., LV-1067 Riga, Latvia. ORCID
Angelika Krumina: Department of Infectology, Riga Stradins University, LV-1007 Riga, Latvia.
Modra Murovska: Institute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites Str., LV-1067 Riga, Latvia. ORCID

PMID: 34439855 DOI: 10.3390/biom11081189

Reliable serum biomarkers are of immense need for diagnostic purposes of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-a disabling and complex disease for which diagnosis is mainly based on clinical symptoms. The aim of this study was to evaluate a possible diagnostic potential of activin B by directly comparing 134 cases of ME/CFS with 54 healthy controls. Analyses of human activin B level in plasma samples were performed using a validated human activin B ELISA assay. The results of the study show that activin B levels did not differ statistically significantly between ME/CFS patients and healthy controls ( = 0.6511). No gender or age-related differences in activin B levels were observed in the ME/CFS group and healthy controls. The level of activin B tended to decrease with increasing visual analogue scale score ( = -0.2004; = 0.5085) nevertheless the results obtained so far does not support the clinical utility of activin B as a biomarker for ME/CFS.

ME/CFS human activin B visual analogue scale

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Adult

Aged

Biomarkers

Case-Control Studies

Fatigue Syndrome, Chronic

Female

Humans

Inhibin-beta Subunits

Male

Middle Aged

Young Adult

Biomarkers

INHBB protein, human

Inhibin-beta Subunits

Journal Article Research Support, Non-U.S. Gov't

Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study.Documenting disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Allostatic overload in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].Immunosignature Analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS.A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci.Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review.

Exploring the joint potential of inflammation, immunity, and receptor-based biomarkers for evaluating ME/CFS progression.EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities.Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review.Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

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