New Insights into the Biology of the Emerging Tembusu Virus.

Rodolphe Hamel, Thipruethai Phanitchat, Sineewanlaya Wichit, Ronald Enrique Morales Vargas, Jiraporn Jaroenpool, Cheikh Tidiane Diagne, Julien Pompon, Dorothée Missé
Author Information
  1. Rodolphe Hamel: MIVEGEC, Univ Montpellier, IRD, CNRS, 34000 Montpellier, France. ORCID
  2. Thipruethai Phanitchat: Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
  3. Sineewanlaya Wichit: Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand. ORCID
  4. Ronald Enrique Morales Vargas: Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. ORCID
  5. Jiraporn Jaroenpool: Medical Technology Department, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.
  6. Cheikh Tidiane Diagne: MIVEGEC, Univ Montpellier, IRD, CNRS, 34000 Montpellier, France. ORCID
  7. Julien Pompon: MIVEGEC, Univ Montpellier, IRD, CNRS, 34000 Montpellier, France. ORCID
  8. Dorothée Missé: MIVEGEC, Univ Montpellier, IRD, CNRS, 34000 Montpellier, France. ORCID

Abstract

Reported for the first time in 1955 in Malaysia, Tembusu virus (TMUV) remained, for a long time, in the shadow of flaviviruses with human health importance such as dengue virus or Japanese encephalitis virus. However, since 2010 and the first large epidemic in duck farms in China, the threat of its emergence on a large scale in Asia or even its spillover into the human population is becoming more and more significant. This review aims to report current knowledge on TMUV from viral particle organization to the development of specific vaccines and therapeutics, with a particular focus on host-virus interactions.

Keywords

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Grants

  1. ANR-15-CE15-00029/Agence Nationale de la Recherche
  2. ANR-10-LABX-04-01/Agence Nationale de la Recherche

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