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Bioelectricity
Mar 01, 2019;1 (1): 35-45.

Bioelectric Properties of Myogenic Progenitor Cells.

Colin Fennelly, Shay Soker
Author Information
  1. Colin Fennelly: Department of Neuroscience, Novartis Institutes for BioMedical Research, Inc., Cambridge, Massachusetts.
  2. Shay Soker: Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina.
PMID: 34471807 DOI: 10.1089/bioe.2018.0002

Abstract

Modern stem cell research has mainly focused on protein expression and transcriptional networks. However, transmembrane voltage gradients generated by ion channels and transporters have demonstrated to be powerful regulators of cellular processes. These physiological cues exert influence on cell behaviors ranging from differentiation and proliferation to migration and polarity. Bioelectric signaling is a fundamental element of living systems and an untapped reservoir for new discoveries. Dissecting these mechanisms will allow for novel methods of controlling cell fate and open up new opportunities in biomedicine. This review focuses on the role of ion channels and the resting membrane potential in the proliferation and differentiation of skeletal muscle progenitor cells. In addition, findings relevant to this topic are presented and potential implications for tissue engineering and regenerative medicine are discussed.

Keywords

bioelectricity differentiation skeletal muscle stem cells

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